Evidence map›Paper›PMID 26526811›Full record

ArticleCellular oncology (Dordrecht, Netherlands)2015

DBD-F induces apoptosis in gastric cancer-derived cells through suppressing HIF2α expression.

Guang-Hui Tong, Wei-Wei Tong, Xiao-Song Qin, Li-Ping Lu, Yong Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular oncology (Dordrecht, Netherlands), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Guang-Hui TongDepartment of Laboratory Medicine, ShengJing Affiliated Hospital, China Medical University, Shenyang, 110004, China.
Wei-Wei TongDepartment of Laboratory Medicine, ShengJing Affiliated Hospital, China Medical University, Shenyang, 110004, China.
Xiao-Song QinDepartment of Laboratory Medicine, ShengJing Affiliated Hospital, China Medical University, Shenyang, 110004, China.
Li-Ping LuDepartment of Laboratory Medicine, ShengJing Affiliated Hospital, China Medical University, Shenyang, 110004, China.
Yong LiuDepartment of Laboratory Medicine, ShengJing Affiliated Hospital, China Medical University, Shenyang, 110004, China. liuyong_sj@163.com.
China Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeGastric cancer is the third leading cause of cancer-related death in China. Accumulating evidence indicates that HIF2α may affect the aggressiveness of gastric cancer. It has also been found that HIF2α C-terminal PAS domains can form complexes with inactive benzoxadiazole antagonists. Here, the anti-tumor effect of 4-(N,Ndimethylaminosulphonyl)-7-fluoro-1,2,3-benzoxadiazole (DBD-F) on human gastric cancer cells was examined using both in vitro and in vivo assays. METHODS AND

resultsWe found that DBD-F can induce apoptosis and inhibit the mobility of MKN28 and MKN45 gastric cancer-derived cells in vitro. We also found that DBD-F can suppress tumor growth in established gastric cancer-derived xenograft models in vivo. Finally, we found that DBD-F can inhibit HIF2α expression in gastric cancer-derived cells.

conclusionsFrom our findings we conclude that DBD-F (i) is cytotoxic to gastric cancer-derived cells and (ii) can induce apoptosis in these cells via the MEK/ERK signaling pathway. In addition, our findings strongly indicate that DBD-F can inhibit HIF2α expression by affecting the phosphorylation status of MEK/ERK in gastric cancer-derived cells.

Indexed as

AnimalsAntineoplastic AgentsApoptosisBasic Helix-Loop-Helix ProteinsBlotting, WesternCell Line, TumorEndothelial PAS Domain-Containing Protein 1Flow CytometryFluorescent Antibody TechniqueHumansImmunohistochemistryMiceMice, NudeOxazolesReverse Transcriptase Polymerase Chain ReactionStomach Neoplasms4-(N,N-dimethylaminosulfonyl)-7-fluoro-2,1,3-benzoxadiazoleAntineoplastic AgentsBasic Helix-Loop-Helix ProteinsEndothelial PAS Domain-Containing Protein 1OxazolesSulfonamidesApoptosisDBD-FGastric cancerHIF2αMEK/ERK

Identifiers

PMID26526811
PMCPMC13004256
OpenAlexW1926171455

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.