ArticleScientific reports2015
Construction and analysis of dynamic transcription factor regulatory networks in the progression of glioma.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Systematic integration of protein-affecting mutations, gene fusions, and copy number alterations into a comprehensive somatic mutational profile.Cell reports methods · 2023Article
- Oncogenic Landscape of Somatic Mutations Perturbing Pan-Cancer lncRNA-ceRNA Regulation.Frontiers in cell and developmental biology · 2021Article
- Systematic analysis of enhancer regulatory circuit perturbation driven by copy number variations in malignant glioma.Theranostics · 2021Article
- Shared Molecular Mechanisms between Alzheimer's Disease and Periodontitis Revealed by Transcriptomic Analysis.BioMed research international · 2021Article
- Dynamic TF-lncRNA Regulatory Networks Revealed Prognostic Signatures in the Development of Ovarian Cancer.Frontiers in bioengineering and biotechnology · 2020Article
- Systematically Dissecting the Function of RNA-Binding Proteins During Glioma Progression.Frontiers in genetics · 2019Article
- Constructing tissue-specific transcriptional regulatory networks via a Markov random field.BMC genomics · 2018Article
- Characterization of Transcriptome Transition Associates Long Noncoding RNAs with Glioma Progression.Molecular therapy. Nucleic acids · 2018Article
- LncMAP: Pan-cancer atlas of long noncoding RNA-mediated transcriptional network perturbations.Nucleic acids research · 2018Article
- Natural Selection in Cancer Biology: From Molecular Snowflakes to Trait Hallmarks.Cold Spring Harbor perspectives in medicine · 2017Review
- Identification and characterization of lncRNA mediated transcriptional dysregulation dictates lncRNA roles in glioblastoma.Oncotarget · 2016Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The combinatorial cross-regulation of transcription factors (TFs) plays an important role in cellular identity and function; however, the dynamic regulation of TFs during glioma progression remains largely unknown. Here, we used the genome-wide expression of TFs to construct an extensive human TF network comprising interactions among 513 TFs and to analyse the dynamics of the TF-TF network during glioma progression. We found that the TF regulatory networks share a common architecture and that the topological structures are conserved. Strikingly, despite the conservation of the network architecture, TF regulatory networks are highly grade specific, and TF circuitry motifs are dynamically rewired during glioma progression. In addition, the most frequently observed structure in the grade-specific TF networks was the feedforward loop (FFL). We described applications that show how investigating the behaviour of FFLs in glioblastoma can reveal FFLs (such as RARG-NR1I2-CDX2) that are associated with prognosis. We constructed comprehensive TF-TF networks and systematically analysed the circuitry, dynamics, and topological principles of the networks during glioma progression, which will further enhance our understanding of the functions of TFs in glioma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.