ArticleSoft matter2016
The twisted tauopathies: surface interactions of helically patterned filaments seen in alzheimer's disease and elsewhere.
Article in Soft matter, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 7 citations in OpenAlex.
- Shape Selection of Surface-Bound Helical Filaments: Biopolymers on Curved Membranes.Biophysical journal · 2016Article
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Authors and funding
2 authors at 2 institutions in 3 countries.
Funding
Abstract
This paper broadly examines the dynamics of helically patterned filaments interacting with a surface and focuses on the surface interaction of amyloid fibrils formed by tau protein. Two structures are addressed in detail: cylindrical filaments with periodic thinning (CF-PT) and paired helical filaments (PHFs). PHFs are observed in neural tissue affected by Alzheimer's disease and may aggregate to form the pathological neurofibrillary tangles associated with the illness. Work using electron microscopy has demonstrated the conversion of CF-PT into PHFs in vitro, suggesting CF-PT to be a PHF precursor in vivo. Here we model CF-PT as a patterned elastic rod placed on a flat surface (characteristic of the environment during microscopy) and examine the conformational changes resulting in stable surface bonding. Analysis of this conformational space reveals structures resembling PHFs and thus provides a mechanistic explanation of the CF-PT to PHF transition. We develop a general phase diagram of the filament conformation as a function of filament twist and bend rigidity. Results of this work also suggest that we can obtain desired filament conformations by patterning interactions of elastic filaments with a substrate, and therefore can be used as a method in microfabrication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.