Trial reportCritical care (London, England)2015
Long-term mortality and risk factors for development of end-stage renal disease in critically ill patients with and without chronic kidney disease.
Trial report in Critical care (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02424747 (Long Term Survival and Renal Outcomes in Critically Ill Patients After Acute Kidney Injury), which is not on this map. Cited by 42 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Long Term Survival and Renal Outcomes in Critically Ill Patients After Acute Kidney Injury: Swedish Multi-centre Cohort Study
Who cites it
42 citing papers in PubMed, 4 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- Risk factors for acute kidney injury in pediatric intensive care units: a systematic review and meta-analysis.BMC pediatrics · 2026Pooled it
- Long-term outcomes following acute kidney injury in individuals with pre-existing chronic kidney disease: a systematic review and meta-analysis.Journal of nephrology · 2025Pooled it
- Effect of clinical decision support systems on clinical outcome for acute kidney injury: a systematic review and meta-analysis.BMC nephrology · 2021Pooled it
- Female sex reduces the risk of hospital-associated acute kidney injury: a meta-analysis.BMC nephrology · 2018Pooled it
- Impact of renal-replacement therapy strategies on outcomes for patients with chronic kidney disease: a secondary analysis of the STARRT-AKI trial.Intensive care medicine · 2022Trial
- Severity of Chronic Kidney Disease and Outcomes After Admission to the Intensive Care Unit.JAMA network open · 2026Article
- Outcomes of acute kidney injury patients with and without chronic kidney disease in intensive care units: a retrospective contrast analysis.BMC medical informatics and decision making · 2026Article
- Age-Specific Prognostic Models for Sepsis-Associated Acute Kidney Injury: A Multicenter Cohort Study.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Renal impairment and in-hospital adverse renal events in critically ill patients assessed by age-adapted estimated glomerular filtration rate criteria.Renal failure · 2025Article
- Development and validation of machine learning models to predict in-hospital mortality in ICU patients with sepsis and chronic kidney disease.BMC infectious diseases · 2025Article
- The Pathogenesis of Chronic Kidney Disease (CKD) and the Preventive and Therapeutic Effects of Natural Products.Current issues in molecular biology · 2025Review
- Association between the blood urea nitrogen to serum albumin ratio and the risk of mortality in patients with chronic kidney disease: a cohort study.BMC nephrology · 2025Article
- Machine learning-based model for the prediction of acute kidney injury following coronary artery bypass graft surgery in elderly Chinese patients.Journal of thoracic disease · 2025Article
- Incidence of acute kidney injury and attributive mortality in acute respiratory distress syndrome randomized trials.Intensive care medicine · 2024Article
- Machine learning algorithm to predict the in-hospital mortality in critically ill patients with chronic kidney disease.Renal failure · 2023Article
- Prediction of acute kidney injury following coronary artery bypass graft surgery in elderly Chinese population.Journal of cardiothoracic surgery · 2023Article
- Risk of malignant disease in 1-year sepsis survivors, a registry-based nationwide follow-up study.Critical care (London, England) · 2023Article
- Prognostic value of PaOThe Journal of international medical research · 2022Article
- Role and Clinical Application of Metagenomic Next-Generation Sequencing in Immunocompromised Patients With Acute Respiratory Failure During Veno-Venous Extracorporeal Membrane Oxygenation.Frontiers in cellular and infection microbiology · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPrevalence of chronic kidney disease (CKD) amongst intensive care unit (ICU) admissions is rising. How mortality and risk of end-stage renal disease (ESRD) differs between those with and without CKD and with acute kidney injury (AKI) is unclear. Determining factors that increase the risk of ESRD is essential to optimise treatment, identify patients requiring nephrological surveillance and for quantification of dialysis provision.
methodThis cohort study used the Swedish intensive care register 2005-2011 consisting of 130,134 adult patients. Incomplete cases were excluded (26,771). Patients were classified (using diagnostic and intervention codes as well as admission creatinine values) into the following groups: ESRD, CKD, AKI, acute-on-chronic disease (AoC) or no renal dysfunction (control). Primary outcome was all-cause mortality. Secondary outcome was ESRD incidence.
resultsOf 103,363 patients 4,192 had pre-existing CKD; 1389 had ESRD; 5273 developed AKI and 998 CKD patients developed AoC. One-year mortality was greatest in AoC patients (54 %) followed by AKI (48.7 %), CKD (47.6 %) and ESRD (40.3 %) (P < 0.001). Five-year mortality was highest for the CKD and AoC groups (71.3 % and 68.2 %, respectively) followed by AKI (61.8 %) and ESRD (62.9 %) (P < 0.001). ESRD incidence was greatest in the AoC and CKD groups (adjusted incidence rate ratio (IRR) 259 (95 % confidence interval (CI) 156.9-429.1) and 96.4, (95 % CI 59.7-155.6) respectively) and elevated in AKI patients compared with controls (adjusted IRR 24 (95 % CI 3.9-42.0); P < 0.001). Risk factors independently associated with ESRD in 1-year survivors were, according to relative risk ratio, AoC (356; 95 % CI 69.9-1811), CKD (267; 95 % CI 55.1-1280), AKI (30; 95 % CI 5.98-154) and presence of elevated admission serum potassium (4.6; 95 % CI 1.30-16.40) (P < 0.001).
conclusionsPre-ICU renal disease significantly increases risk of death compared with controls. Subjects with AoC disease had extreme risk of developing ESRD. All patients with CKD who survive critical care should receive a nephrology referral.
trial registrationCLINICAL TRIALS REGISTRATION NUMBER: NCT02424747 April 20th 2015.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.