ReviewNature reviews. Neurology2015
Nonconventional MRI and microstructural cerebral changes in multiple sclerosis.
Review in Nature reviews. Neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it, 132 citations in OpenAlex.
- Early diagnosis of secondary progressive multiple sclerosis: focus on fluid and neurophysiological biomarkers.Journal of neurology · 2021Pooled it
- Exercise training effects on memory and hippocampal viscoelasticity in multiple sclerosis: a novel application of magnetic resonance elastography.Neuroradiology · 2017Trial
- Longitudinal myelin MR imaging in patients with multiple sclerosis: a narrative review.Journal of neurology · 2026Review
- Label-free tracking of subcortical white matter degradationBiomedical optics express · 2026Article
- Imaging markers of neuroinflammation in aging and Alzheimer's disease and related dementia: A comprehensive review.Neuroscience and biobehavioral reviews · 2025Review
- White Matter Magnetic Resonance Diffusion Measures in Multiple Sclerosis with Overactive Bladder.Brain sciences · 2024Article
- Review
- Microstructural changes of peripheral nerves in early multiple sclerosis: A prospective magnetic resonance neurography study.European journal of neurology · 2024Article
- Protocol of a prospective multicenter study on comorbidity impact on multiple sclerosis and antibody-mediated diseases of the central nervous system (COMMIT).Frontiers in immunology · 2024Article
- Using quantitative magnetic resonance imaging to track cerebral alterations in multiple sclerosis brain: A longitudinal study.Brain and behavior · 2023Article
- Microstructural mapping of dentate gyrus pathology in Alzheimer's disease: A 16.4 Tesla MRI study.NeuroImage. Clinical · 2023Article
- The Key Role of Magnetic Resonance Imaging in the Detection of Neurodegenerative Diseases-Associated Biomarkers: A Review.Molecular neurobiology · 2022Review
- Fibrin-targeting molecular MRI in inflammatory CNS disorders.European journal of nuclear medicine and molecular imaging · 2022Article
- Magnetic Resonance Imaging in Primary Progressive Multiple Sclerosis Patients : Review.Clinical neuroradiology · 2022Review
- Advanced MRI quantification of neuroinflammatory disorders.Journal of neuroscience research · 2022Article
- The central vein sign helps in differentiating multiple sclerosis from its mimickers: lessons from Fabry disease.European radiology · 2022Article
- Magnetization Transfer Ratio of Peripheral Nerve and Skeletal Muscle : Correlation with Demographic Variables in Healthy Volunteers.Clinical neuroradiology · 2022Article
- Detection of subtle white matter lesions in MRI through texture feature extraction and boundary delineation using an embedded clustering strategy.Scientific reports · 2022Article
- Multifunctional carbon nanomaterials for diagnostic applications in infectious diseases and tumors.Materials today. Bio · 2022Review
- Magnetic susceptibility anisotropy in normal appearing white matter in multiple sclerosis from single-orientation acquisition.NeuroImage. Clinical · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 7 institutions in 7 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MRI has become the most important paraclinical tool for diagnosing and monitoring patients with multiple sclerosis (MS). However, conventional MRI sequences are largely nonspecific in the pathology they reveal, and only provide a limited view of the complex morphological changes associated with MS. Nonconventional MRI techniques, such as magnetization transfer imaging (MTI), diffusion-weighted imaging (DWI) and susceptibility-weighted imaging (SWI) promise to complement existing techniques by revealing more-specific information on microstructural tissue changes. Past years have witnessed dramatic advances in the acquisition and analysis of such imaging data, and numerous studies have used these tools to probe tissue alterations associated with MS. Other MRI-based techniques-such as myelin-water imaging, (23)Na imaging, magnetic resonance elastography and magnetic resonance perfusion imaging-might also shed new light on disease-associated changes. This Review summarizes the rapid technical progress in the use of MRI in patients with MS, with a focus on nonconventional structural MRI. We critically discuss the present utility of nonconventional MRI in MS, and provide an outlook on future applications, including clinical practice. This information should allow appropriate selection of advanced MRI techniques, and facilitate their use in future studies of this disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.