Evidence map›Paper›PMID 26526387›Full record

ArticleIranian journal of basic medical sciences2015

The trophic effect of ciliary neurotrophic factor on injured masseter muscle in rat.

Yujun Zhang, Xiaohui Wang, Mengmeng Zhang, Xuefen Lin, Qingting Wu, Yingying Yang, Jingjing Kong, Ping Ji

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Iranian journal of basic medical sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yujun ZhangShandong Provincial Key Laboratory of Oral Biomedicine, College of Stomatology, Shandong University, Jinan City, Shandong Province, China. Postcode: 250012.
Xiaohui WangCollege of Stomatology, Taishan Medical College, Taian City, Shandong Province, China.
Mengmeng ZhangShandong Provincial Key Laboratory of Oral Biomedicine, College of Stomatology, Shandong University, Jinan City, Shandong Province, China. Postcode: 250012.
Xuefen LinShandong Provincial Key Laboratory of Oral Biomedicine, College of Stomatology, Shandong University, Jinan City, Shandong Province, China. Postcode: 250012.
Qingting WuShandong Provincial Key Laboratory of Oral Biomedicine, College of Stomatology, Shandong University, Jinan City, Shandong Province, China. Postcode: 250012.
Yingying YangShandong Provincial Key Laboratory of Oral Biomedicine, College of Stomatology, Shandong University, Jinan City, Shandong Province, China. Postcode: 250012.
Jingjing KongShandong Provincial Key Laboratory of Oral Biomedicine, College of Stomatology, Shandong University, Jinan City, Shandong Province, China. Postcode: 250012.
Ping JiShandong Provincial Key Laboratory of Oral Biomedicine, College of Stomatology, Shandong University, Jinan City, Shandong Province, China. Postcode: 250012.
Shandong University · CNTaishan Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesOcclusal trauma is one of the most common forms of oral biting dysfunction. Long-term occlusal trauma could weaken the stomatognathic system; especially damage one's masticatory muscle. Through using the rat model, this study investigated the trophic effect of ciliary neurotrophic factor (CNTF) on injured masseter muscle. MATERIALS AND

methodsMale Wistar rats (n=36) were randomly divided into five experimental groups and one control group (6 rats per group). Animals in the experimental group were cemented modified crowns on their mandibular first molars to artificially induce occlusal trauma in 1, 3, 7, 14, and 28 days. Control group was sham-treated with forced mouth-opening for about 5 min, while no crowns were placed. After 28 days of treatment, all rats were euthanized and their masseter muscle was collected. Through immunofluorescence and real-time quantitative PCR, the expression of desmin, CNTF, and CNTFRα was investigated in rat masseter muscle. The microstructure of masseter muscle was observed by transmission electron microscope.

resultsThe expression of desmin showed a time-dependent decrease on traumatic and non-traumatic sides masseter, until reached the nadir at the 14(th) day, then restored to its normal level at the 28(th) day; however, the expression of CNTF and CNTFRα on the traumatic and non-traumatic sides increased from day 7, reached the peak at the 14(th) day, and returned to normal level on the 28(th) day.

conclusionCNTF, as an important neurotrophic factor, was tightly associated to the restoring of rat injured masseter muscle, which provides new target and treatment method for clinical application.

Indexed as

Ciliary neurotrophic factorCNTFRαDesminMasseter muscleOcclusal trauma

Identifiers

PMID26526387
PMCPMC4620193
OpenAlexW2318393002

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.