ArticleAutism research : official journal of the International Society for Autism Research2016
Biochemistry of the cingulate cortex in autism: An MR spectroscopy study.
Article in Autism research : official journal of the International Society for Autism Research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Neurometabolite differences in Autism as assessed with Magnetic Resonance Spectroscopy: A systematic review and meta-analysis.Neuroscience and biobehavioral reviews · 2024Pooled it
- Neurometabolite levels in the brains of patients with autism spectrum disorders: A meta-analysis of proton magnetic resonance spectroscopy studies (N = 1501).Molecular psychiatry · 2023Pooled it
- Adaptive Whole-Brain Dynamics Predictive Method: Relevancy to Mental Disorders.Research (Washington, D.C.) · 2025Article
- Neurochemical differences in core regions of the autistic brain: a multivoxelScientific reports · 2024Article
- The Lack of Alterations in Metabolites in the Medial Prefrontal Cortex and Amygdala, but Their Associations with Autistic Traits, Empathy, and Personality Traits in Adults with Autism Spectrum Disorder: A Preliminary Study.Journal of autism and developmental disorders · 2024Article
- Developmental brain structural atypicalities in autism: a voxel-based morphometry analysis.Child and adolescent psychiatry and mental health · 2022Article
- Prediction learning in adults with autism and its molecular correlates.Molecular autism · 2021Article
- Concentrations of Cortical GABA and Glutamate in Young Adults With Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2020Article
- Parsing the Heterogeneity of Brain Metabolic Disturbances in Autism Spectrum Disorder.Biological psychiatry · 2020Article
- Revisiting the excitation/inhibition imbalance hypothesis of ASD through a clinical lens.The British journal of radiology · 2019Review
- Shifting brain inhibitory balance and connectivity of the prefrontal cortex of adults with autism spectrum disorder.Translational psychiatry · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Neuroimaging studies have uncovered structural and functional alterations in the cingulate cortex in individuals with autism spectrum disorders (ASD). Such abnormalities may underlie neurochemical imbalance. In order to characterize the neurochemical profile, the current study examined the concentration of brain metabolites in dorsal ACC (dACC) and posterior cingulate cortex (PCC) in high-functioning adults with ASD. Twenty high-functioning adults with ASD and 20 age-and-IQ-matched typically developing (TD) peers participated in this Proton magnetic resonance spectroscopy (1H-MRS) study. LCModel was used in analyzing the spectra to measure the levels of N-Acetyl aspartate (NAA), choline (Cho), creatine (Cr), and glutamate/glutamine (Glx) in dACC and PCC. Groups were compared using means for the ratio of each metabolite to their respective Cr levels as well as on absolute internal-water-referenced measures of each metabolite. There was a significant increase in Cho in PCC for ASD adults, with a marginal increase in dACC. A reduction in NAA/Cr in dACC was found in ASD participants, compared to their TD peers. No significant differences in Glx/Cr or Cho/Cr were found in dACC. There were no statistically significant group differences in the absolute concentration of NAA, Cr, Glx, or NAA/Cr, Cho/Cr, and Glx/Cr in the PCC. Differences in the metabolic properties of dACC compared to PCC were also found. Results of this study provide evidence for possible cellular and metabolic differences in the dACC and PCC in adults with ASD. This may suggest neuronal dysfunction in these regions and may contribute to the neuropathology of ASD. Autism Res 2016, 9: 643-657. © 2015 International Society for Autism Research, Wiley Periodicals, Inc.
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Registered trials
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