ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2016
Trajectories of Neuropsychiatric Symptoms and Cognitive Decline in Mild Cognitive Impairment.
Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Cognitive and psychological characteristics in patients with Cerebral Amyloid Angiopathy: a literature review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Pooled it
- Effect of online tDCS to left somatomotor cortex on neuropsychiatric symptoms among older adults at risk for dementia.Cortex; a journal devoted to the study of the nervous system and behavior · 2023Trial
- Dynamic trajectories of neuropsychiatric symptoms predict Alzheimer's disease risk and clinical phenotypes.General psychiatry · 2026Article
- Psychiatric Risk Factors for Progression From Mild Cognitive Impairment to Alzheimer's Disease: A Systematic Review.The American journal of geriatric psychiatry. Open science, education, and practice · 2025Article
- Predicting the onset of dementia with longitudinal performance-based measures of physical function.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Latent classes and progression of Mini-Mental State Examination scores in young-onset dementia: Data from the Swedish Dementia Register.Journal of Alzheimer's disease : JAD · 2025Article
- Salivaomics: New Frontiers in Studying the Relationship Between Periodontal Disease and Alzheimer's Disease.Metabolites · 2025Review
- Neuropsychiatric symptoms and neuroimaging-based brain age in mild cognitive impairment and early dementia: A multicenter study.Psychiatry and clinical neurosciences · 2025Article
- Seeking the neural basis of neuropsychiatric symptoms in dementia: neuroimaging findings and controversies.Frontiers in aging neuroscience · 2025Review
- Neuropsychiatric symptoms predict rate of change in executive function in Alzheimer's disease and related dementias.Journal of the International Neuropsychological Society : JINS · 2025Article
- Emotion regulation in people living with dementia and their spouses: the role of neuropsychiatric symptoms.Aging & mental health · 2024Article
- Efficacy of Home-Based Remotely Supervised Transcranial Direct Current Stimulation for Managing Neuropsychiatric Symptoms in Older Adults With Alzheimer's Disease and Related Dementias.Integrative and complementary therapies · 2024Article
- Neuropsychiatric symptoms and lifelong mental activities in cerebral amyloid angiopathy - a cross-sectional study.Alzheimer's research & therapy · 2024Article
- Unique transcriptional signatures correlate with behavioral and psychological symptom domains in Alzheimer's disease.Translational psychiatry · 2024Article
- Cognition Mediates the Association Between Cerebrospinal Fluid Biomarkers of Amyloid and P-Tau and Neuropsychiatric Symptoms.Journal of Alzheimer's disease : JAD · 2024Article
- Impact of Mild Behavioral Impairment on Longitudinal Changes in Cognition.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Brain network correlates of affective symptoms in aMCI.Aging brain · 2024Article
- Openness and age influence cognitive progression: a longitudinal study.Arquivos de neuro-psiquiatria · 2023Article
- Classification and prediction of cognitive trajectories of cognitively unimpaired individuals.Frontiers in aging neuroscience · 2023Article
- Measuring emotion recognition: Added value in diagnosing dementia of the Alzheimer's disease type.Journal of neuropsychology · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo characterize the course of neuropsychiatric symptoms (NPS) in adults with mild cognitive impairment (MCI), and to examine baseline individual-level predictors and associated cognitive and functional outcomes.
designA 2-year prospective cohort study.
settingMulticenter clinical settings.
participantsFive hundred sixty individuals with MCI at baseline. MEASUREMENTS: NPS severity (measured using Neuropsychiatric Inventory Questionnaire) and cognitive and functional outcomes were assessed at baseline and every 6 months thereafter. Potential individual-level predictors were collected at baseline.
resultsThree latent classes of NPS courses were identified using growth mixture modeling: a stable class in which a low NPS burden remained relatively unchanged over time (N = 503, 89.8%); a worsened class in which an initially moderate NPS burden increased (N = 39, 7.0%); and an improved class in which an initially high NPS burden decreased (N = 18, 3.2%). There were no associations between class membership and baseline individual characteristics. Members of the worsened class were 1.74 times more likely to be diagnosed with incident Alzheimer disease (AD) than members of the stable class (95% confidence interval: 1.07-2.84). The worsened class also showed significantly more rapid declines in cognitive and functional outcomes than the stable class. Class membership did not predict rate of brain atrophy.
conclusionsPatients with MCI may experience different trajectories of NPS over time. Patients with worsening NPS may be at greater risk of developing AD and severe cognitive and functional impairment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.