ReviewChromosoma2016
Telomere homeostasis in mammalian germ cells: a review.
Review in Chromosoma, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 56 citations in OpenAlex.
- Meiotic cohesin RAD21L shapes 3D genome structure and transcription in the male germline.Science advances · 2025Article
- mAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Canine sperm motility is associated with telomere shortening and changes in expression of shelterin genes.BMC veterinary research · 2023Article
- Cohesin SMC1β promotes closed chromatin and controls TERRA expression at spermatocyte telomeres.Life science alliance · 2023Article
- Article
- Review
- Male Germ Cell Telomeres and Chemical Pollutants.Biomolecules · 2023Review
- Is sperm telomere length altered in teratozoospermia specimens? A case-control study.International journal of reproductive biomedicine · 2023Article
- Short telomeres impede germ cell specification by upregulating MAPK and TGFβ signaling.Science China. Life sciences · 2023Article
- TERRA beyond cancer: the biology of telomeric repeat-containing RNAs in somatic and germ cells.Frontiers in aging · 2023Review
- Fragile, unfaithful and persistent Ys-on how meiosis can shape sex chromosome evolution.Heredity · 2022Article
- 3D chromatin remodelling in the germ line modulates genome evolutionary plasticity.Nature communications · 2022Article
- Article
- Strategies for meiotic sex chromosome dynamics and telomeric elongation in Marsupials.PLoS genetics · 2022Article
- Article
- Telomere Dysfunction in Oocytes and Embryos From Obese Mice.Frontiers in cell and developmental biology · 2021Article
- Article
- Anti-cancer Immunotherapies Targeting Telomerase.Cancers · 2020Review
- The deteriorating soma and the indispensable germline: gamete senescence and offspring fitness.Proceedings. Biological sciences · 2019Article
- Three-Dimensional Genomic Structure and Cohesin Occupancy Correlate with Transcriptional Activity during Spermatogenesis.Cell reports · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Telomeres protect against genome instability and participate in chromosomal movements during gametogenesis, especially in meiosis. Thus, maintaining telomere structure and telomeric length is essential to both cell integrity and the production of germ cells. As a result, alteration of telomere homeostasis in the germ line may result in the generation of aneuploid gametes or gametogenesis disruption, triggering fertility problems. In this work, we provide an overview on fundamental aspects of the literature regarding the organization of telomeres in mammalian germ cells, paying special attention to telomere structure and function, as well as the maintenance of telomeric length during gametogenesis. Moreover, we discuss the different roles recently described for telomerase and TERRA in maintaining telomere functionality. Finally, we review how new findings in the field of reproductive biology underscore the role of telomere homeostasis as a potential biomarker for infertility. Overall, we anticipate that the study of telomere stability and equilibrium will contribute to improve diagnoses of patients; assess the risk of infertility in the offspring; and in turn, find new treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.