Evidence map›Paper›PMID 26525865›Full record

ArticleBioorganic & medicinal chemistry letters2015

A selective delta opioid receptor antagonist based on a stilbene core.

Alyssa M Hartung, Hernan A Navarro, David F Wiemer, Jeffrey D Neighbors

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Alyssa M HartungDepartment of Chemistry, The University of Iowa, Chemistry Building, Iowa City, IA 52242-1294, United States.
Hernan A NavarroDiscovery Sciences, RTI International, Research Triangle Park, NC 27709, United States.
David F WiemerDepartment of Chemistry, The University of Iowa, Chemistry Building, Iowa City, IA 52242-1294, United States.
Jeffrey D NeighborsDepartment of Chemistry, The University of Iowa, Chemistry Building, Iowa City, IA 52242-1294, United States; Department of Pharmacology, Pennsylvania State University Hershey College of Medicine, Hershey, PA 17033, United States; Penn State Hershey Cancer Institute, Hershey, PA 17033, United States.
University of Iowa · USPenn State Milton S. Hershey Medical Center · USRTI International · US

Funding

Pawhuskins: Potential Treatments for Stimulant Abuse.R03DA026573 · NIDA · UNIVERSITY OF IOWA · PI NEIGHBORS, JEFFREY D · 2009 to 2010
$418k
NIDA NIH HHS DA02-6573NIDA NIH HHS R03 DA026573
6 · The paper itself

Abstract

Studies of directed ortho metalation reactions on an aromatic substrate with multiple potential directing groups have identified conditions that favor either of two regioisomers. One of these regioisomers has been converted to an analogue of the stilbene pawhuskin A, and been shown to have high selectivity as an antagonist of the delta opioid receptor. Docking studies have suggested that this compound can adopt a conformation similar to naltrindole, a known delta antagonist.

Indexed as

HumansMolecular Docking SimulationMolecular StructureNarcotic AntagonistsReceptors, Opioid, deltaStilbenesTerpenesNarcotic Antagonistspawhuskin Apawhuskin BReceptors, Opioid, deltaStilbenesTerpenesDelta receptorDirected ortho metalationDockingOpioidPawhuskin

Identifiers

PMID26525865
PMCPMC4645280
OpenAlexW1781173861

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.