Evidence map›Paper›PMID 26525794›Full record

ArticleAntimicrobial agents and chemotherapy2016

Double Copies of bla(KPC-3)::Tn4401a on an IncX3 Plasmid in Klebsiella pneumoniae Successful Clone ST512 from Italy.

Daniela Fortini, Laura Villa, Claudia Feudi, João Pires, Celestino Bonura, Caterina Mammina, Andrea Endimiani, Alessandra Carattoli

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Review
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  4. Mobile genetic elements inJournal of bacteriology · 2025
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  7. Article
  8. Persistence and Dissemination Capacities of aAntibiotics (Basel, Switzerland) · 2022
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. First Report of OXA-181-ProducingInfection and drug resistance · 2020
    Article
  14. An IncR Plasmid Harbored by a Hypervirulent Carbapenem-ResistantAntimicrobial agents and chemotherapy · 2019
    Article
  15. Article
  16. Article
  17. Article
  18. The rapid spread of carbapenem-resistant Enterobacteriaceae.Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Daniela FortiniDepartment of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome, Italy.
Laura VillaDepartment of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome, Italy.
Claudia FeudiDepartment of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome, Italy.
João PiresInstitute for Infectious Diseases, University of Bern, Bern, Switzerland Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland.
Celestino BonuraDepartment of Sciences for Health Promotion and Mother-Child Care G. D'Alessandro, University of Palermo, Palermo, Italy.
Caterina MamminaDepartment of Sciences for Health Promotion and Mother-Child Care G. D'Alessandro, University of Palermo, Palermo, Italy.
Andrea EndimianiInstitute for Infectious Diseases, University of Bern, Bern, Switzerland.ORCID http://orcid.org/0000-0003-3186-5421
Alessandra CarattoliDepartment of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome, Italy Institute for Infectious Diseases, University of Bern, Bern, Switzerland alecara@iss.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A carbapenem-resistant sequence type 512 (ST512) Klebsiella pneumoniae carbapenemase 3 (KPC-3)-producing K. pneumoniae strain showing a novel variant plasmid content was isolated in Palermo, Italy, in 2014. ST512 is a worldwide successful clone associated with the spread of bla(KPC) genes located on the IncFIIk pKpQIL plasmid. In our ST512 strain, the bla(KPC-3) gene was unusually located on an IncX3 plasmid, whose complete sequence was determined. Two copies of bla(KPC-3)::Tn4401a caused by intramolecular transposition events were detected in the plasmid.

Indexed as

DNA Transposable ElementsGene Expression Regulation, BacterialAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasesCarbapenemsClone CellsDrug Resistance, Multiple, BacterialGene DosageItalyKlebsiella InfectionsKlebsiella pneumoniaeMicrobial Sensitivity TestsOpen Reading FramesPlasmidsAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasescarbapenemaseCarbapenemsDNA Transposable Elements

Identifiers

PMID26525794
PMCPMC4704230

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.