ArticleTetrahedron2015
Spiroscytalin, a new tetramic acid and other metabolites of mixed biogenesis from Scytalidium cuboideum.
Article in Tetrahedron, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
11 citing papers in PubMed.
- Towards a reduced-background cell factory: disruption of a PKS-NRPS hybrid gene (AlepA) abolishing the production of 2-pyridones in Aspergillus oryzae.World journal of microbiology & biotechnology · 2026Article
- Species-specific gene regulatory network rewiring mediated by the GATA-type regulator NsdD inmBio · 2025Article
- Article
- Phylogenetic assessment and taxonomic revision ofIMA fungus · 2025Article
- Penicillides fromMolecules (Basel, Switzerland) · 2024Review
- Polyketides with potential bioactivities from the mangrove-derived fungusMarine life science & technology · 2023Article
- Secondary Metabolites from Coral-Associated Fungi: Source, Chemistry and Bioactivities.Journal of fungi (Basel, Switzerland) · 2022Review
- Development and Utilization of a Palladium-Catalyzed Dehydration of Primary Amides To Form Nitriles.Organic letters · 2018Article
- qNMR for profiling the production of fungal secondary metabolites.Magnetic resonance in chemistry : MRC · 2017Article
- Prealamethicin F50 and related peptaibols fromRSC advances · 2017Article
- Chemoinformatic expedition of the chemical space of fungal products.Future medicinal chemistry · 2016Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Spiroscytalin (1), a new tetramic acid that possesses an uncommon spiro-ring fusion between a polyketide-derived octalin ring system and a 2,4-pyrrolidinedione, along with two known compounds, leporin B (2) and purpactin A (3), were isolated from a solid phase culture of the fungus Scytalidium cuboideum (MSX 68345). The molecular connectivity of 1-3 was determined using NMR spectroscopy and mass spectrometry. The relative configurations of 1 and 2 were determined by NOESY experiments. The absolute configuration of 1 was determined by electronic circular dichroism (ECD) via a combination of experimental measurements and computational calculations. While leporin B was known, it displayed activities that had not been reported previously, including cytotoxicity against three human tumor cell lines and antibacterial activity against Candida albicans and Staphylococcus aureus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.