Evidence map›Paper›PMID 26525562›Full record

Trial reportEuropean journal of nutrition2017

Association between body weight and composition and plasma 25-hydroxyvitamin D level in the Diabetes Prevention Program.

Lisa Ceglia, Jason Nelson, James Ware, Konstantinos-Dionysios Alysandratos, George A Bray, Cheryl Garganta, David M Nathan, Frank B Hu, Bess Dawson-Hughes, Anastassios G Pittas and 1 more

Open access · greenAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 36 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Observational
  6. Article
  7. Article
  8. Observational
  9. An Updated Mini Review of Vitamin D and Obesity: Adipogenesis and Inflammation State.Open access Macedonian journal of medical sciences · 2016
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Lisa CegliaDivision of Endocrinology, Diabetes and Metabolism, Tufts Medical Center, Box 268, 800, Washington Street, #268, Boston, MA, 02111, USA. lisa.ceglia@tufts.edu.
Jason NelsonInstitute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA.
James WareDepartment of Biostatistics, Harvard School of Public Health, Boston, MA, USA.
Konstantinos-Dionysios AlysandratosDivision of Neurology, Boston University Medical Center, Boston, MA, USA.
George A BrayPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA.
Cheryl GargantaDepartment of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainsville, FL, USA.
David M NathanDiabetes Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Frank B HuDepartments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA, USA.
Bess Dawson-HughesDivision of Endocrinology, Diabetes and Metabolism, Tufts Medical Center, Box 268, 800, Washington Street, #268, Boston, MA, 02111, USA.
Anastassios G PittasDivision of Endocrinology, Diabetes and Metabolism, Tufts Medical Center, Box 268, 800, Washington Street, #268, Boston, MA, 02111, USA.
Diabetes Prevention Program Research Group
Tufts Medical Center · USHarvard University · USBoston Medical Center · USBrigham and Women's Hospital · USPennington Biomedical Research Center · USTufts University · USUniversity of Florida · US

Funding

PRIMARY PREVENTION TRIAL--DATA COORDINATING CENTERU01DK048489 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI JABLONSKI, KATHLEEN ANN, TEMPROSA, MARINELLA · 1994 to 2021
$84.8M
Vitamin D and Type 2 Diabetes (D2d)U01DK098245 · NIDDK · TUFTS MEDICAL CENTER · PI PITTAS, ANASTASSIOS G · 2013 to 2020
$45.6M
Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Julie Mathieu · 1986 to 2026
$41.4M
TUFTS CLINICAL AND TRANSLATION SCIENCE INSTITUTE (UL1): BPCAUL1RR025752 · NCRR · TUFTS UNIVERSITY BOSTON · PI SELKER, HARRY P. · 2008 to 2011
$17.6M
Post-DDP Follow-up StudyU01DK048413 · NIDDK · UNIVERSITY OF WASHINGTON · PI KAHN, STEVEN EMANUEL · 1994 to 2021
$13.7M
PRIMARY PREVENTION TRIAL (DPT-2)U01DK048397 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI NATHAN, DAVID M · 1994 to 2021
$12.0M
NIDDM PRIMARY PREVENTION TRIAL (DPT 2)U01DK048404 · NIDDK · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI LAFERRERE, BLANDINE B · 1994 to 2021
$11.6M
NIDDM PRIMARY PREVENTION TRIALU01DK048412 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VENDITTI, ELIZABETH MARY · 1994 to 2021
$11.4M
PRIMARY PREVENTION TRIALU01DK048387 · NIDDK · MEDSTAR RESEARCH INSTITUTE · PI MAGEE, MICHELLE FISCHMANN · 1994 to 2022
$11.1M
TITLE OMITTEDU01DK048349 · NIDDK · YESHIVA UNIVERSITY · PI CRANDALL, JILL P · 1994 to 2021
$11.0M
Post-DPP Follow-up StudyU01DK048375 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI DABELEA, DANA · 1994 to 2022
$10.0M
Post-Diabetes Prevention Program (DPP)U01DK048381 · NIDDK · UNIVERSITY OF CHICAGO · PI EHRMANN, DAVID A · 1994 to 2021
$9.6M
NCRR NIH HHS UL1 RR025752NIDDK NIH HHS P30 DK017047NIDDK NIH HHS R01 DK078907NIDDK NIH HHS R01 DK079003NIDDK NIH HHS U01 DK048349NIDDK NIH HHS U01 DK048375NIDDK NIH HHS U01 DK048377NIDDK NIH HHS U01 DK048380NIDDK NIH HHS U01 DK048381NIDDK NIH HHS U01 DK048387NIDDK NIH HHS U01 DK048397NIDDK NIH HHS U01 DK048400NIDDK NIH HHS U01 DK048404NIDDK NIH HHS U01 DK048406NIDDK NIH HHS U01 DK048407NIDDK NIH HHS U01 DK048411NIDDK NIH HHS U01 DK048412NIDDK NIH HHS U01 DK048413NIDDK NIH HHS U01 DK048434NIDDK NIH HHS U01 DK048437NIDDK NIH HHS U01 DK048468NIDDK NIH HHS U01 DK048485NIDDK NIH HHS U01 DK048489NIDDK NIH HHS U01 DK048514NIDDK NIH HHS U01 DK098245
6 · The paper itself

Abstract

objectiveWe examined associations between body weight and plasma 25-hydroxyvitamin D concentration (25OHD) in prediabetes and sought to estimate the impact of adiposity on these associations.

methodsThe study was conducted in the placebo (n = 1082) and intensive lifestyle (n = 1079) groups of the Diabetes Prevention Program (DPP), a multicenter trial to prevent type 2 diabetes in adults with prediabetes. Weight and 25OHD were measured at baseline, month 6, years 1 and 2. In a subset (n = 584), visceral (VAT) and subcutaneous (SAT) adiposity were assessed by computed tomography at baseline and year 1.

resultsIn cross-sectional analyses, baseline body weight, total fat, VAT, and SAT were inversely associated with plasma 25OHD concentration after multivariable adjustment. VAT accounted for 40 % [95 % CI 11, 69] of the association of body weight with plasma 25OHD concentration. There was no significant contribution by total fat or SAT. Two-year changes in plasma 25OHD concentration varied inversely with changes in body weight (p < 0.0001). One-year changes in total fat, VAT, or SAT were not significant mediators of the association between change in plasma 25OHD concentration and body weight.

conclusionOur study found an inverse association between body weight and plasma 25OHD concentration at baseline and over a 2-year period in adults with prediabetes. These findings in the DPP, a weight loss intervention study, raise the possibility that weight loss increases plasma 25OHD concentration. Whether adiposity mediates this association remains inconclusive.

Indexed as

Body CompositionBody WeightAdiposityAdultBody Mass IndexCross-Sectional StudiesDiabetes Mellitus, Type 2FemaleFollow-Up StudiesHumansIntra-Abdominal FatLife StyleLinear ModelsLongitudinal StudiesMaleMiddle Aged25-hydroxyvitamin DVitamin DAdipose tissueBody compositionBody weightDiabetes Prevention ProgramObesityVitamin D

Identifiers

PMID26525562
PMCPMC5121080
OpenAlexW1912422415

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.