Evidence map›Paper›PMID 26525494›Full record

ArticleThe journal of physical chemistry. C, Nanomaterials and interfaces2015

Metal-Dielectric Waveguides for High Efficiency Fluorescence Imaging.

Liangfu Zhu, Douguo Zhang, Ruxue Wang, Pei Wang, Hai Ming, Ramachandram Badugu, Luping Du, Xiaocong Yuan, Joseph R Lakowicz

Abstract read
In one paragraph

Article in The journal of physical chemistry. C, Nanomaterials and interfaces, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Liangfu ZhuInstitute of Photonics, Department of Optics and Optical Engineering, University of Science and Technology of China, Hefei, Anhui, 230026, China.
Douguo ZhangInstitute of Photonics, Department of Optics and Optical Engineering, University of Science and Technology of China, Hefei, Anhui, 230026, China.
Ruxue WangInstitute of Photonics, Department of Optics and Optical Engineering, University of Science and Technology of China, Hefei, Anhui, 230026, China.
Pei WangInstitute of Photonics, Department of Optics and Optical Engineering, University of Science and Technology of China, Hefei, Anhui, 230026, China.
Hai MingInstitute of Photonics, Department of Optics and Optical Engineering, University of Science and Technology of China, Hefei, Anhui, 230026, China.
Ramachandram BaduguCenter for Fluorescence Spectroscopy, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 725 West Lombard St., Baltimore, MD 21201, United States.
Luping DuInstitute of Micro & Nano Optics, College of Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.
Xiaocong YuanInstitute of Micro & Nano Optics, College of Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.
Joseph R LakowiczCenter for Fluorescence Spectroscopy, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 725 West Lombard St., Baltimore, MD 21201, United States.

Funding

Metallic Surfaces and Particles in DNA AnalysisR01HG002655 · NHGRI · UNIVERSITY OF MARYLAND BALTIMORE · PI LAKOWICZ, JOSEPH R. · 2003 to 2012
$2.8M
Plasmon-Controlled Fluorescence and Cardiac MarkersR01EB006521 · NIBIB · UNIVERSITY OF MARYLAND BALTIMORE · PI LAKOWICZ, JOSEPH R. · 2007 to 2015
$2.7M
Diffusion-Enhanced Lanthanide Nanoparticle FRET AssaysR21GM107986 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE · PI LAKOWICZ, JOSEPH R. · 2014 to 2016
$568k
Bioaffinity Assays Using UV One-Dimensional Photonic Crystals (1DPC)R21EB018959 · NIBIB · UNIVERSITY OF MARYLAND BALTIMORE · PI LAKOWICZ, JOSEPH R. · 2015 to 2016
$420k
Multi-User Time-Resolved Fluorescence SpectrometerS10OD019975 · OD · UNIVERSITY OF MARYLAND BALTIMORE · PI LAKOWICZ, JOSEPH R. · 2015 to 2015
$243k
NHGRI NIH HHS R01 HG002655NIBIB NIH HHS R01 EB006521NIBIB NIH HHS R21 EB018959NIGMS NIH HHS R21 GM107986NIH HHS S10 OD019975
6 · The paper itself

Abstract

We demonstrate that Metal-Dielectric Waveguide structures (MDWs) with high efficiency of fluorescence coupling can be suitable as substrates for fluorescence imaging. This hybrid MDWs consists of a continuous metal film and a dielectric top layer. The optical modes sustaining inside this structure can be excited with a high numerical aperture (N.A) objective, and then focused into a virtual optical probe with high intensity, leading to efficient excitation of fluorophores deposited on top of the MDWs. The emitted fluorophores couple with the optical modes thus enabling the directional emission, which is verified by the back focal plane (BFP) imaging. These unique properties of MDWs have been adopted in a scanning laser confocal optical microscopy, and show the merit of high efficiency fluorescence imaging. MDWs can be easily fabricated by vapor deposition and/or spin coating, the silica surface of the MDWs is suitable for biomolecule tethering, and will offer new opportunities for cell biology and biophysics research.

Identifiers

PMID26525494
PMCPMC4627712

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.