ReviewCold Spring Harbor perspectives in medicine2015
Past, Present, and Future of Healthy Life Expectancy.
Review in Cold Spring Harbor perspectives in medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
75 citing papers in PubMed.
- Reduced sensitivity to tactile stimuli associated with physical and mental disorders: A monozygotic twin study.Scientific reports · 2026Article
- Why healthy life expectancy estimates diverge: insights from survey-based, administrative, and model-based metrics across Japanese prefectures, 2001-2019: a comparative ecological study.Population health metrics · 2026Article
- Qualitative Experiences of Older Adults Participating in a Student-Delivered Community Outreach TeleheAlth Program for COVID Education and Health Promotion.Health promotion practice · 2026Article
- Getting better or worse? How trends in healthy life expectancy within working age are shaped by diverging trends among age groups.European journal of public health · 2026Article
- Population-level analysis of chronic disease multimorbidity at older ages across time using mixed graphical models.Archives of public health = Archives belges de sante publique · 2026Article
- Integrating rapid response systems and patient centered goals of care discussions.Frontiers in medicine · 2026Article
- Forms of support giving and receiving, and their associations with self-rated health and general self-efficacy among older adults in Switzerland.Frontiers in psychology · 2026Article
- Demographic Change and the Future of Austria's Long-Term-Care Allowance: A Dynamic Microsimulation Study.Healthcare (Basel, Switzerland) · 2025Article
- The Future Dynamics of Long-Term Care Pressure in China's Longevity Era: A Prediction Based on the Discrete-Time Markov Model.Healthcare (Basel, Switzerland) · 2025Article
- A Generative Framework for Predictive Modeling of Multiple Chronic Conditions Using Graph Variational Autoencoder and Bandit-Optimized Graph Neural Network.IEEE journal of biomedical and health informatics · 2025Article
- Analysis of health information needs of elderly patients with chronic diseases based on Kano Model: a descriptive cross-sectional study.BMC geriatrics · 2025Article
- Synthetic Data-Enhanced Classification of Prevalent Osteoporotic Fractures Using Dual-Energy X-Ray Absorptiometry-Based Geometric and Material Parameters.Endocrinology and metabolism (Seoul, Korea) · 2025Article
- The Social Division of Care Work Time Over Half a Century.Demography · 2025Article
- Outliving and outlasting: explaining sex inequities in healthy life expectancy through the lens of multimorbidity and within morbidities in older populations in India.Frontiers in public health · 2025Article
- Estimating the Sex Gap in Depression-Free Life Expectancy Among Widowed Americans Aged 50 and Older: An Application Using the Interpolated Markov Chain Approach.Journal of aging and health · 2025Article
- ICT, health expenditures, and healthy life expectancy: empirical evidence from the Sub-Saharan African states.Frontiers in public health · 2025Article
- Extra-Skeletal Manifestations in Osteogenesis Imperfecta Mouse Models.Calcified tissue international · 2024Review
- Medication-based profiling of older orthopedic patients: a multicenter cross-sectional study.BMC geriatrics · 2024Article
- Trends of Gaps Between Health-Adjusted Life Expectancy and Life Expectancy at the Regional Level in Korea Using a Group-Based Multi-Trajectory Modeling Approach (2008-2019).Journal of Korean medical science · 2024Article
- The Healthspan Project: A Retrospective Pilot of Biomarkers and Biometric Outcomes after a 6-Month Multi-Modal Wellness Intervention.Healthcare (Basel, Switzerland) · 2024Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The success of the current biomedical paradigm based on a "disease model" may be limited in the future because of large number of comorbidities inflicting older people. In recent years, there has been growing empirical evidence, based on animal models, suggesting that the aging process could be delayed and that this process may lead to increases in life expectancy accompanied by improvements in health at older ages. In this review, we explore past, present, and future prospects of healthy life expectancy and examine whether increases in average length of life associated with delayed aging link with additional years lived disability-free at older ages. Trends in healthy life expectancy suggest improvements among older people in the United States, although younger cohorts appear to be reaching old age with increasing levels of frailty and disability. Trends in health risk factors, such as obesity and smoking, show worrisome signs of negative impacts on adult health and mortality in the near future. However, results based on a simulation model of delayed aging in humans indicate that it has the potential to increase not only the length of life but also the fraction and number of years spent disability-free at older ages. Delayed aging would likely come with additional aggregate costs. These costs could be offset if delayed aging is widely applied and people are willing to convert their greater healthiness into more years of work.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.