Evidence map›Paper›PMID 26525196›Full record

ArticlePediatric nephrology (Berlin, Germany)2016

Urinary markers in the early stage of nephropathy in patients with childhood-onset type 1 diabetes.

Jin-Soon Suh, Shin-Hee Kim, Kyoung Soon Cho, In-Ah Jung, Won Kyoung Cho, Yeon Jin Jeon, Min Ho Jung, Byoung Kyu Suh

Abstract readEvaluation Study
PubMed Publisher
In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Urinary L-FABP: A Novel Biomarker for Evaluating Diabetic Nephropathy Onset and Progression. A Narrative Review.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025
    Review
  6. Review
  7. Article
  8. Review
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jin-Soon SuhDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Shin-Hee KimDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Kyoung Soon ChoDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
In-Ah JungDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Won Kyoung ChoDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Yeon Jin JeonDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Min Ho JungDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, South Korea. jmhpe@catholic.ac.kr.ORCID http://orcid.org/0000-0003-3906-1014
Byoung Kyu SuhDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, South Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this study was to evaluate the association of a urinary tubular marker, liver-type fatty acid binding protein (L-FABP) and an inflammatory marker, serum/urinary YKL-40, with albuminuria in patients with childhood-onset type 1 diabetes (T1D).

methodsTwenty-nine patients with childhood-onset T1D and 32 controls were enrolled. Serum and urinary concentrations of YKL-40 and urinary concentrations of L-FABP were measured.

resultsThe serum levels of YKL-40 were not significantly different between the control group and the patient groups. However, the levels of urinary YKL-40/creatinine (Cr) were higher in the patients, even those with normoalbuminuria than in the controls (p < 0.001). The levels of urinary L-FABP/Cr were not different between the control group and the patient groups. However, the level of urinary L-FABP/Cr in the microalbuminuria group was higher than that in the normoalbuminuria group (p = 0.03). There were no associations between the levels of urinary albumin-to-creatinine ratio and urinary L-FABP/Cr or YKL-40/Cr. However, the urinary L-FABP/Cr level was significantly correlated with the hemoglobin A1C level (p = 0.005) and the urinary YKL-40/Cr level (p = 0.043).

conclusionsUrinary L-FABP/Cr and YKL-40/Cr may reflect renal injury in early stages of nephropathy in patients with childhood-onset T1D, even in the normoalbuminuric state.

Indexed as

AdolescentAge of OnsetAlbuminuriaBiomarkersCase-Control StudiesChildChitinase-3-Like Protein 1CreatinineCross-Sectional StudiesDiabetes Mellitus, Type 1Diabetic NephropathiesEarly DiagnosisFatty Acid-Binding ProteinsHumansMalePredictive Value of TestsBiomarkersCHI3L1 protein, humanChitinase-3-Like Protein 1CreatinineFABP1 protein, humanFatty Acid-Binding ProteinsAlbuminuriaBiomarkersChildrenDiabetic nephropathyLiver-type fatty acid binding proteinYKL-40

Identifiers

PMID26525196

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.