Evidence map›Paper›PMID 26525178›Full record

ArticleProcesses (Basel, Switzerland)2015

A Computational Study of the Effects of Syk Activity on B Cell Receptor Signaling Dynamics.

Reginald L McGee, Mariya O Krisenko, Robert L Geahlen, Ann E Rundell, Gregery T Buzzard

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Processes (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Reginald L McGeeDepartment of Mathematics, Purdue University, 150 N. University St., West Lafayette, IN 47907, USA.
Mariya O KrisenkoDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 201 S. University Street, West Lafayette, IN 47907, USA.
Robert L GeahlenDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 201 S. University Street, West Lafayette, IN 47907, USA.
Ann E RundellWeldon School of Biomedical Engineering, Purdue University, 206 S. Martin Jischke Drive, West Lafayette, IN 47907, USA.
Gregery T BuzzardDepartment of Mathematics, Purdue University, 150 N. University St., West Lafayette, IN 47907, USA.

Funding

Tyrosine Kinases and Lymphocyte ActivationR01AI098132 · NIAID · PURDUE UNIVERSITY · PI GEAHLEN, ROBERT L · 2012 to 2016
$1.6M
NIAID NIH HHS R01 AI098132
6 · The paper itself

Abstract

The kinase Syk is intricately involved in early signaling events in B cells and is required for proper response when antigens bind to B cell receptors (BCRs). Experiments using an analog-sensitive version of Syk (Syk-AQL) have better elucidated its role, but have not completely characterized its behavior. We present a computational model for BCR signaling, using dynamical systems, which incorporates both wild-type Syk and Syk-AQL. Following the use of sensitivity analysis to identify significant reaction parameters, we screen for parameter vectors that produced graded responses to BCR stimulation as is observed experimentally. We demonstrate qualitative agreement between the model and dose response data for both mutant and wild-type kinases. Analysis of our model suggests that the level of NF-

Indexed as

B cell signalingcell responsecomputational modelingmutant Syksignal transduction

Identifiers

PMID26525178
PMCPMC4627698

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.