ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2016
Aging-Related Considerations When Evaluating the Forced Expiratory Volume in 1 Second (FEV1) Over Time.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Functional, molecular, and digital measurements of biological age.The Journal of clinical investigation · 2026Review
- Occupation and 11-year lung function decline in the HUNT Study.Occupational medicine (Oxford, England) · 2025Article
- Changes in children's lung function over two decades in relation to socioeconomic, parental and household factors in Wuhan, China.Journal of thoracic disease · 2021Article
- Assessing the Tidal Volume through Wearables: A Scoping Review.Sensors (Basel, Switzerland) · 2021Article
- A roadmap to build a phenotypic metric of ageing: insights from the Baltimore Longitudinal Study of Aging.Journal of internal medicine · 2020Article
- FEVRespiratory care · 2020Article
- Relative and absolute lung function change in a general population aged 60-102 years.The European respiratory journal · 2019Article
- Selection of a set of biomarkers and comparisons of biological age estimation models for Korean men.Journal of exercise rehabilitation · 2019Article
- Lung Function Trajectory in Bronchiolitis Obliterans Syndrome after Allogeneic Hematopoietic Cell Transplant.Annals of the American Thoracic Society · 2016Article
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8 authors.
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Abstract
backgroundForced expiratory volume in 1 second (FEV1) over time is commonly expressed in liters and percent predicted (%Pred), or alternatively in L/m(3) and Z-scores-which approach is more clinically meaningful has not been evaluated. Because it uniquely accounts for the effect of aging on FEV1 and spirometric performance, we hypothesized that the Z-score approach is more clinically meaningful, based on associations between cardiopulmonary predictors and FEV1 over time.
methodsUsing linear mixed-effects models and data from the Baltimore Longitudinal Study on Aging, including 501 white participants aged 40-95 who had completed at least three longitudinal spirometric assessments, we evaluated the associations between cardiopulmonary predictors (obesity, smoking status, hypertension, chronic bronchitis, diabetes mellitus, and myocardial infarction) and FEV1 over time, in liters, %Pred, L/m(3), and Z-scores.
resultsMean baseline values for FEV1 were 3.240L, 96.4%Pred, 0.621L/m(3), and -0.239 as a Z-score (40.6th percentile). The annual decline in FEV1 was 0.040L, 0.234 %Pred, 0.007L/m(3), and 0.008 Z-score units. Baseline age was associated with FEV1 over time in liters and L/m(3) (p < .001), and included a time interaction for %Pred (p < .001), but was not associated with Z-scores (p = .933). The associations of cardiopulmonary predictors with FEV1 over time were all significant when using Z-scores (p < .05), but varied for other methods of expressing FEV1.
conclusionA Z-score approach is more clinically meaningful when evaluating FEV1 over time, as it accounted for the effect of aging and was more frequently associated with multiple cardiopulmonary predictors.
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