ArticleThe Pan African medical journal2015
Factors associated with major structural birth defects among newborns delivered at Muhimbili National Hospital and Municipal Hospitals in Dar Es Salaam, Tanzania 2011 - 2012.
Article in The Pan African medical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 5 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- A Silent Epidemic of Congenital Anomalies and Its Predictors Among Newborns in Ethiopia: A Systematic Review and Meta-Analysis.Public health reviews · 2026Pooled it
- The effect of folic acid intake on congenital anomalies. A systematic review and meta-analysis.Frontiers in pediatrics · 2024Pooled it
- Congenital anomalies and risk factors in Africa: a systematic review and meta-analysis.BMJ paediatrics open · 2023Pooled it
- Magnitude and determinants of neural tube defect in Africa: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2021Pooled it
- Prevalence and associated factors of birth defects among newborns in sub-Saharan African countries: a systematic review and meta-analysis.The Pan African medical journal · 2020Pooled it
- Cumulative evidence for the association between maternal hypertension and cleft lip and palate in offspring: a systematic review and meta-analysis.Frontiers in oral health · 2026Review
- A retrospective study of congenital anomalies and associated risk factors among children admitted at a tertiary hospital in northwestern Tanzania.PLOS global public health · 2024Article
- Burden of Neural Tube Defects and Their Associated Factors in Africa: A Systematic Review and Meta-Analysis.International journal of pediatrics · 2023Review
- Prevalence of Congenital Anomaly and Its Relationship with Maternal Education and Age According to Local Development in the Extreme South of Brazil.International journal of environmental research and public health · 2022Observational
- Congenital anomalies among newborn babies in Felege-Hiwot Comprehensive Specialized Referral Hospital, Bahir Dar, Ethiopia.Scientific reports · 2021Article
- The Operative Incidence of Syndactyly in Northern Ireland. A 10-Year Review.The Ulster medical journal · 2021Review
- Determinants and seasonality of major structural birth defects among newborns delivered at primary and referral hospital of East and West Gojjam zones, Northwest Ethiopia 2017-2018: case-control study.BMC research notes · 2019Article
- Congenital anomalies prevalence in Addis Ababa and the Amhara region, Ethiopia: a descriptive cross-sectional study.BMC pediatrics · 2019Article
- Factors associated with congenital anomalies in Addis Ababa and the Amhara Region, Ethiopia: a case-control study.BMC pediatrics · 2018Article
- Magnitude of Birth Defects in Central and Northwest Ethiopia from 2010-2014: A Descriptive Retrospective Study.PloS one · 2016Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
introductionNinety-four percent of all birth defects and 95% of deaths due to the birth defects occur in low and middle income countries, Tanzania among them. In Tanzania there are currently limited birth defects prevention strategies in place due to limited information on factors associated with the occurrence of birth defects.
methodsWe conducted a case control study that included newborns born from October, 2011 through February, 2012 at 4 participating hospitals. A case was defined as any newborn of a Dar es salaam resident with a neural tube defect, orofacial clefts, limb reduction defects or musculo-skeletal defects (SBD) born during the study period. A control was defined as the next three newborns (delivered after the case) without birth defects. Univariate, bivariate and multivariate analysis were done using Epi Info version 3.5.1.
resultsA total of 400 newborns participated in the study, 100 cases and 300 controls. Factors associated with higher odds of a SBD included maternal fever (adjusted odds ratio (AOR) = 1.99; 95% confidence interval (CI): 1.14-3.52), maternal hypertension (AOR = 3.99; 95% CI: 1.67-9.54), and low birth weight (AOR = 3.48; 95% CI: 1.77-6.85). Antimalarial use during pregnancy was protective (AOR = 0.48; 95% CI: 0.28-0.84). Folic acid supplementation was protective only in bivariate analysis (OR = 0.56; 95% CI: 0.32-0.96).
conclusionMaternal fever, hypertension, and low birth weight are associated with higher odds of SBD. Antimalarial use during pregnancy was associated with lower odds of SBD. Early screening of pregnant mothers for hypertension and other causes of low birth weight may reduce SBD in Dar Es Salaam.
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