Evidence map›Paper›PMID 26525044›Full record

ArticleSystematic reviews2015

Integrating multiple data sources (MUDS) for meta-analysis to improve patient-centered outcomes research: a protocol.

Evan Mayo-Wilson, Susan Hutfless, Tianjing Li, Gillian Gresham, Nicole Fusco, Jeffrey Ehmsen, James Heyward, Swaroop Vedula, Diana Lock, Jennifer Haythornthwaite and 11 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Systematic reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors at 3 institutions in 1 country.

Evan Mayo-WilsonCenter for Clinical Trials and Evidence Synthesis, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD, 21205, USA. evan.mayo-wilson@jhu.edu.
Susan HutflessCenter for Clinical Trials and Evidence Synthesis, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD, 21205, USA.
Tianjing LiCenter for Clinical Trials and Evidence Synthesis, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD, 21205, USA.
Gillian GreshamCenter for Clinical Trials and Evidence Synthesis, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD, 21205, USA.
Nicole FuscoCenter for Clinical Trials and Evidence Synthesis, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD, 21205, USA.
Jeffrey EhmsenDepartment of Neurology, Johns Hopkins School of Medicine, 855 North Wolfe Street, Baltimore, MD, 21205, USA.
James HeywardCenter for Clinical Trials and Evidence Synthesis, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD, 21205, USA.
Swaroop VedulaLaboratory for Computational Sensing and Robotics, Johns Hopkins Whiting School of Engineering, 3400 North Charles St., Baltimore, MD, 21218, USA.
Diana LockDepartment of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD, 21205, USA.
Jennifer HaythornthwaiteBehavioral Biology, Center for Mind-Body Research, Johns Hopkins School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, 21224, MD, USA.
Jennifer L PaynePsychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, 500 North Broadway, Suite 305, Baltimore, MD, 21205, USA.
Theresa CowleyThe TMJ Association, Ltd., P.O. Box 26770, Milwaukee, WI, 53226-0770, USA.
Elizabeth TolbertPeabody Institute, Johns Hopkins University, 1 East Mount Vernon Place, Baltimore, MD, 21202, USA.
Lori RosmanWelch Medical Library, Johns Hopkins School of Medicine, 615 North Wolfe Street, Baltimore, MD, 21205, USA.
Claire TwoseWelch Medical Library, Johns Hopkins School of Medicine, 615 North Wolfe Street, Baltimore, MD, 21205, USA.
Elizabeth A StuartDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, 624 North Broadway, Baltimore, MD, 21205, USA.
Hwanhee HongDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, 624 North Broadway, Baltimore, MD, 21205, USA.
Peter DoshiUniversity of Maryland School of Pharmacy, 220 Arch Street, Baltimore, MD, 21201, USA.
Catalina Suarez-CuervoDepartment of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD, 21205, USA.
Sonal SinghCenter for Public Health and Human Rights, Johns Hopkins School of Medicine, 615 N Wolfe St, Baltimore, MD, 21205, USA.
Kay DickersinCenter for Clinical Trials and Evidence Synthesis, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD, 21205, USA.
Johns Hopkins University · USTMJ Association · USUniversity of Maryland, Baltimore · US

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
NCATS NIH HHS UL1 TR001079
6 · The paper itself

Abstract

backgroundSystematic reviews should provide trustworthy guidance to decision-makers, but their credibility is challenged by the selective reporting of trial results and outcomes. Some trials are not published, and even among clinical trials that are published partially (e.g., as conference abstracts), many are never published in full. Although there are many potential sources of published and unpublished data for systematic reviews, there are no established methods for choosing among multiple reports or data sources about the same trial.

methodsWe will conduct systematic reviews of the effectiveness and safety of two interventions following the Institute of Medicine (IOM) guidelines: (1) gabapentin for neuropathic pain and (2) quetiapine for bipolar depression. For the review of gabapentin, we will include adult participants with neuropathic pain who do not require ventilator support. For the review of quetiapine, we will include adult participants with acute bipolar depression (excluding mixed or rapid cycling episodes). We will compare these drugs (used alone or in combination with other interventions) with placebo or with the same intervention alone; direct comparisons with other medications will be excluded. For each review, we will conduct highly sensitive electronic searches, and the results of the searches will be assessed by two independent reviewers. Outcomes, study characteristics, and risk of bias ratings will be extracted from multiple reports by two individuals working independently, stored in a publicly available database (Systematic Review Data Repository) and analyzed using commonly available statistical software. In each review, we will conduct a series of meta-analyses using data from different sources to determine how the results are affected by the inclusion of data from multiple published sources (e.g., journal articles and conference abstracts) as well as unpublished aggregate data (e.g., "clinical study reports") and individual participant data (IPD). We will identify patient-centered outcomes in each report and identify differences in the reporting of these outcomes across sources. SYSTEMATIC REVIEW REGISTRATION: CRD42015014037 , CRD42015014038.

Indexed as

Meta-Analysis as TopicResearch DesignAminesAnalgesicsAntipsychotic AgentsBipolar DisorderCyclohexanecarboxylic AcidsData Interpretation, StatisticalGabapentingamma-Aminobutyric AcidHumansNeuralgiaOutcome Assessment, Health CarePatient-Centered CareQuetiapine FumarateSelection BiasAminesAnalgesicsAntipsychotic AgentsCyclohexanecarboxylic AcidsGabapentingamma-Aminobutyric AcidQuetiapine Fumarate

Identifiers

PMID26525044
PMCPMC4630908
OpenAlexW2138484034

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.