ArticleObesity (Silver Spring, Md.)2015
A new look at the genetic and environmental coherence of metabolic syndrome components.
Article in Obesity (Silver Spring, Md.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Cross-Cultural Perspectives on Metabolic Syndrome Management and Attitudes Toward Using Digital Health Tools in Two Distinct Populations: Protocol for a Qualitative Descriptive Study.JMIR research protocols · 2026Article
- Article
- Clinical features and prognosis of COVID-19 patients with metabolic syndrome: A multicenter, retrospective study.Medicina clinica · 2022Article
- Clinical features and prognosis of COVID-19 patients with metabolic syndrome: A multicenter, retrospective study.Medicina clinica (English ed.) · 2022Article
- Genome-wide association analysis of metabolic syndrome quantitative traits in the GENNID multiethnic family study.Diabetology & metabolic syndrome · 2021Article
- Body mass trajectories and cortical thickness in middle-aged men: a 42-year longitudinal study starting in young adulthood.Neurobiology of aging · 2019Article
- Steeper change in body mass across four decades predicts poorer cardiometabolic outcomes at midlife.Obesity (Silver Spring, Md.) · 2017Article
- Genetics of Insulin Resistance and the Metabolic Syndrome.Current cardiology reports · 2016Review
- Ability of dairy fat in inducing metabolic syndrome in rats.SpringerPlus · 2016Article
- Genetic Underpinnings of Increased BMI and Its Association With Late Midlife Cognitive Abilities.Gerontology & geriatric medicineArticle
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
objectiveMetabolic syndrome, a clustering of risk factors including insulin resistance, dyslipidemia, central obesity, and hypertension, increases risk for cardiovascular disease and cognitive decline. The etiology of the risk factors' cohesion remains unclear. How genetic and environmental influences explained co-occurrence of metabolic syndrome components was examined.
methodsContinuous measures of body mass index (BMI), waist circumference, blood pressure (BP), fasting insulin and glucose, high-density lipoprotein cholesterol (HDL), and triglycerides from 1,193 middle-aged twin men participating in the Vietnam Era Twin Study of Aging at average age 62 (range 56-67) were analyzed using multivariate biometrical modeling.
resultsFour heritable factors were found: adiposity (BMI, waist circumference), insulin resistance (glucose, insulin), lipids (HDL, triglycerides), and BP (systolic, diastolic). Heritabilities were 0.42-0.68. In the best-fitting model, insulin resistance, lipids, and adiposity comprised a higher-order latent genetic factor. Adiposity and BP shared genetic influences independent of the latent genetic factor. All factors aggregated on a latent unique environmental factor.
conclusionsMetabolic syndrome components form the equivalent of two genetic factors. BP was genetically unrelated to insulin resistance and lipids. Adiposity was the only characteristic genetically and environmentally related to all other factors. These results inform strategies for gene discovery and prediction of health outcomes.
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