ArticleNature nanotechnology2016
A stochastic DNA walker that traverses a microparticle surface.
Article in Nature nanotechnology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed.
- A DNA triangular prism scaffold-guided directionally-controlled derailment-free DNAzyme walker.Journal of advanced research · 2026Article
- Sensitive detection of Salmonella enterica subsp. enterica serovar typhimurium based on antibody-aptamer dual recognition and DNA walker signal amplification.Mikrochimica acta · 2026Article
- Programming DNA machines to move.Nature reviews. Chemistry · 2026Review
- A multifunctional approach: merging CRISPR/Cas technology with DNA nanomachines for advanced biosensing.Analytical and bioanalytical chemistry · 2026Review
- Functions and applications of enzymes in nucleic acid nanotechnology.Journal of nanobiotechnology · 2025Review
- DNA Motors Powered by Exonuclease III for Autonomous Rolling Motion and Biosensing Applications.bioRxiv : the preprint server for biology · 2025Article
- A Dual-Cycle Isothermal Amplification Method for microRNA Detection: Combination of a Duplex-Specific Nuclease Enzyme-Driven DNA Walker with Improved Catalytic Hairpin Assembly.International journal of molecular sciences · 2025Article
- An inverted tetrahedron-mediated DNA walker for sulfadimethoxine detection.Mikrochimica acta · 2024Article
- Spatially Localized Entropy-Driven Evolution of Nucleic Acid-Based Constitutional Dynamic Networks for Intracellular Imaging and Spatiotemporal Programmable Gene Therapy.Journal of the American Chemical Society · 2024Article
- Article
- The motive forces in DNA-enabled nanomachinery.iScience · 2024Review
- Pushing Forward the DNA Walkers in Connection with Tumor-Derived Extracellular Vesicles.International journal of nanomedicine · 2024Review
- Mechanics of dynamic and deformable DNA nanostructures.Chemical science · 2023Review
- Controllable mitochondrial aggregation and fusion by a programmable DNA binder.Chemical science · 2023Article
- Structure and dynamics of an archetypal DNA nanoarchitecture revealed via cryo-EM and molecular dynamics simulations.Nature communications · 2023Article
- Cascaded, Feedback-Driven, and Spatially Localized Emergence of Constitutional Dynamic Networks Driven by Enzyme-Free Catalytic DNA Circuits.Journal of the American Chemical Society · 2023Article
- Engineering of catalytic hairpin-rigidified Y-shaped DNA-functionalized nanomachine to rapidly detect mRNA.Mikrochimica acta · 2023Article
- Recent Advances in DNA Origami-Engineered Nanomaterials and Applications.Chemical reviews · 2023Review
- A Target Recycling Amplification Process for the Digital Detection of Exosomal MicroRNAs through Photonic Resonator Absorption Microscopy.Angewandte Chemie (International ed. in English) · 2023Article
- Three-phase DNA-origami stepper mechanism based on multi-leg interactions.Biophysical journal · 2022Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors.
Funding
Abstract
Molecular machines have previously been designed that are propelled by DNAzymes, protein enzymes and strand displacement. These engineered machines typically move along precisely defined one- and two-dimensional tracks. Here, we report a DNA walker that uses hybridization to drive walking on DNA-coated microparticle surfaces. Through purely DNA:DNA hybridization reactions, the nanoscale movements of the walker can lead to the generation of a single-stranded product and the subsequent immobilization of fluorescent labels on the microparticle surface. This suggests that the system could be of use in analytical and diagnostic applications, similar to how strand exchange reactions in solution have been used for transducing and quantifying signals from isothermal molecular amplification assays. The walking behaviour is robust and the walker can take more than 30 continuous steps. The traversal of an unprogrammed, inhomogeneous surface is also due entirely to autonomous decisions made by the walker, behaviour analogous to amorphous chemical reaction network computations, which have been shown to lead to pattern formation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.