ArticleObesity (Silver Spring, Md.)2015
Disconnect between adipose tissue inflammation and cardiometabolic dysfunction in Ossabaw pigs.
Article in Obesity (Silver Spring, Md.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- Type of diet has no major influence on inflammatory response in a Saddleback pig model.Scientific reports · 2025Article
- Female prediabetic rats are protected from vascular dysfunction: the role of nitroso and sulfide signaling.Biological research · 2024Article
- Despite similar clinical features metabolomics reveals distinct signatures in insulin resistant and progressively obese minipigs.Journal of physiology and biochemistry · 2023Article
- ADAM17 cleaves the insulin receptor ectodomain on endothelial cells and causes vascular insulin resistance.American journal of physiology. Heart and circulatory physiology · 2022Article
- Article
- The right ventricular transcriptome signature in Ossabaw swine with cardiometabolic heart failure: implications for the coronary vasculature.Physiological genomics · 2021Article
- Large Animal Models of Heart Failure: A Translational Bridge to Clinical Success.JACC. Basic to translational science · 2020Review
- Molecular cloning of SLC35D3 and analysis of its role during porcine intramuscular preadipocyte differentiation.BMC genetics · 2020Article
- Perivascular Adipose Tissue as an Indication, Contributor to, and Therapeutic Target for Atherosclerosis.Frontiers in physiology · 2020Review
- Chronic Elevation of Endothelin-1 Alone May Not Be Sufficient to Impair Endothelium-Dependent Relaxation.Hypertension (Dallas, Tex. : 1979) · 2019Article
- Western Diet-Fed, Aortic-Banded Ossabaw Swine: A Preclinical Model of Cardio-Metabolic Heart Failure.JACC. Basic to translational science · 2019Article
- Immune Response of Piglets Receiving Mixture of Formic and Propionic Acid Alone or with Either Capric Acid orBioMed research international · 2019Article
- Cecal versus fecal microbiota in Ossabaw swine and implications for obesity.Physiological genomics · 2018Article
- The Ossabaw Pig Is a Suitable Translational Model to Evaluate Dietary Patterns and Coronary Artery Disease Risk.The Journal of nutrition · 2018Article
- Microvascular insulin resistance in skeletal muscle and brain occurs early in the development of juvenile obesity in pigs.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Endothelial dysfunction occurs independently of adipose tissue inflammation and insulin resistance in ovariectomized Yucatan miniature-swine.Adipocyte · 2018Article
- High-fat, high-fructose, high-cholesterol feeding causes severe NASH and cecal microbiota dysbiosis in juvenile Ossabaw swine.American journal of physiology. Endocrinology and metabolism · 2018Article
- Effect of Caloric Restriction on Metabolic Dysfunction of Young Rapacz Familial Hypercholesterolemic Swine (Comparative medicine · 2017Article
- Deletion of UCP1 enhances ex vivo aortic vasomotor function in female but not male mice despite similar susceptibility to metabolic dysfunction.American journal of physiology. Endocrinology and metabolism · 2017Article
- Absence of Endothelial ERα Results in Arterial Remodeling and Decreased Stiffness in Western Diet-Fed Male Mice.Endocrinology · 2017Article
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveThe Ossabaw pig is emerging as an attractive model of human cardiometabolic disease because of its size and susceptibility to atherosclerosis, among other characteristics. The relationship between adipose tissue inflammation and metabolic dysfunction in this model was investigated here.
methodsYoung female Ossabaw pigs were fed a Western-style high-fat diet (HFD) (n = 4) or control low-fat diet (LFD) (n = 4) for a period of 9 months and compared for cardiometabolic outcomes and adipose tissue inflammation.
resultsThe HFD-fed "OBESE" pigs were 2.5 times heavier (P < 0.001) than LFD-fed "LEAN" pigs and developed severe obesity. HFD feeding caused pronounced dyslipidemia, hypertension, and insulin resistance (systemic and adipose), as well as induction of inflammatory genes, impairments in vasomotor reactivity to insulin, and atherosclerosis in the coronary arteries. Remarkably, visceral, subcutaneous, and perivascular adipose tissue inflammation (via FACS analysis and RT-PCR) was not increased in OBESE pigs, nor were circulating inflammatory cytokines.
conclusionsThese findings reveal a disconnect between adipose tissue inflammation and cardiometabolic dysfunction induced by Western diet feeding in the Ossabaw pig model.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.