ReviewObesity (Silver Spring, Md.)2015
Measuring breath acetone for monitoring fat loss: Review.
Review in Obesity (Silver Spring, Md.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 65 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Characterization of a Portable Solid-State Breath Acetone Testing Device for Real-Time Ketosis Status and Comparison to Blood Ketone Testing
A Prospective, Non-interventional, Observational Clinical Validation Study to Analytically Validate the A&M Breathalyzer PROTECT Kiosk Breath Capture System.
Who cites it
65 citing papers in PubMed, 203 citations in OpenAlex.
- Randomized controlled trial of time-restricted eating: secondary analyses of breath acetone.International journal of obesity (2005) · 2025Trial
- Keyto app and device versus WW app on weight loss and metabolic risk in adults with overweight or obesity: A randomized trial.Obesity (Silver Spring, Md.) · 2021Trial
- Skin acetone as a clinical diagnostic biomarker of ketosis.Nutrition & diabetes · 2026Article
- Correlation Between Breath Acetone and Ketone Bodies in Blood and Urine Among Individuals with Different Glycometabolic Statuses Based on PTR-TOF-MS.Diagnostics (Basel, Switzerland) · 2026Article
- Local heating increases skin gas acetone content independent of systemic metabolism.Scientific reports · 2026Article
- Challenges and opportunities of wearable molecular sensors in endocrinology and metabolism.Nature reviews. Endocrinology · 2026Review
- Breathomics in Diabetes Management: A Noninvasive Approach for Precision Health Monitoring.Journal of diabetes research · 2026Review
- Intermittent Hypoxia-Induced Inflammation and the Formation of Exhaled Volatile Organic Compound Profiles in Obstructive Sleep Apnea-Hypopnea Syndrome: A Narrative Review.Nature and science of sleep · 2026Review
- Effects of hyperbaric air exposure with oxygen breathing during decompression on the exhaled volatile organic compounds.Frontiers in physiology · 2026Article
- Long-Term Weight Loss in Adults With Overweight or Obesity Using a Breath Biofeedback mHealth App: A One-Year Follow-Up of a Randomized Trial.Obesity science & practice · 2025Article
- Associations between breath acetone overnight dynamics and obstructive sleep apnea manifestations.BMC pulmonary medicine · 2025Article
- Confounder-Invariant Representation Learning (CIRL) for Robust Olfaction with Scarce Aroma Sensor Data: Mitigating Humidity Effects in Breath Analysis.Sensors (Basel, Switzerland) · 2025Article
- Breath Analysis via Surface Enhanced Raman Spectroscopy.ACS sensors · 2025Review
- Exhaled Breath Analysis: From Laboratory Test to Wearable Sensing.IEEE reviews in biomedical engineering · 2025Review
- The role of β-hydroxybutyrate testing in ketogenic metabolic therapies.Frontiers in nutrition · 2025Review
- Detection ofSensors (Basel, Switzerland) · 2024Article
- Effects of a Carbohydrate Meal on Lipolysis.Nutrients · 2024Article
- An inexpensive UV-LED photoacoustic based real-time sensor-system detecting exhaled trace-acetone.Photoacoustics · 2024Article
- A study of 9 common breath VOCs in 504 healthy subjects using PTR-TOF-MS.Metabolomics : Official journal of the Metabolomic Society · 2024Article
- Chemical Analysis of Exhaled Vape Emissions: Unraveling the Complexities of Humectant Fragmentation in a Human Trial Study.Chemical research in toxicology · 2024Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveEndogenous acetone production is a by-product of the fat metabolism process. Because of its small size, acetone appears in exhaled breath. Historically, endogenous acetone has been measured in exhaled breath to monitor ketosis in healthy and diabetic subjects. Recently, breath acetone concentration (BrAce) has been shown to correlate with the rate of fat loss in healthy individuals. In this review, the measurement of breath acetone in healthy subjects is evaluated for its utility in predicting fat loss and its sensitivity to changes in physiologic parameters.
resultsBrAce can range from 1 ppm in healthy non-dieting subjects to 1,250 ppm in diabetic ketoacidosis. A strong correlation exists between increased BrAce and the rate of fat loss. Multiple metabolic and respiratory factors affect the measurement of BrAce. BrAce is most affected by changes in the following factors (in descending order): dietary macronutrient composition, caloric restriction, exercise, pulmonary factors, and other assorted factors that increase fat metabolism or inhibit acetone metabolism. Pulmonary factors affecting acetone exchange in the lung should be controlled to optimize the breath sample for measurement.
conclusionsWhen biologic factors are controlled, BrAce measurement provides a non-invasive tool for monitoring the rate of fat loss in healthy subjects.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.