ArticleJournal of the mechanical behavior of biomedical materials2015
A microstructurally inspired damage model for early venous thrombus.
Article in Journal of the mechanical behavior of biomedical materials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Data-driven continuum damage mechanics with built-in physics.Extreme Mechanics Letters · 2024Article
- Synthetic hydrogels as blood clot mimicking wound healing materials.Progress in biomedical engineering (Bristol, England) · 2021Article
- Non-invasive Inference of Thrombus Material Properties with Physics-Informed Neural Networks.Computer methods in applied mechanics and engineering · 2021Article
- Structure, mechanical properties, and modeling of cyclically compressed pulmonary emboli.Journal of the mechanical behavior of biomedical materials · 2020Article
- Characterization of human female breast and abdominal skin elasticity using a bulge test.Journal of the mechanical behavior of biomedical materials · 2020Article
- Recent advances in computational modeling of fibrin clot formation: A review.Computational biology and chemistry · 2019Review
- Mechanical response of human female breast skin under uniaxial stretching.Journal of the mechanical behavior of biomedical materials · 2017Article
- Modeling Soft Tissue Damage and Failure Using a Combined Particle/Continuum Approach.Biomechanics and modeling in mechanobiology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Accumulative damage may be an important contributor to many cases of thrombotic disease progression. Thus, a complete understanding of the pathological role of thrombus requires an understanding of its mechanics and in particular mechanical consequences of damage. In the current study, we introduce a novel microstructurally inspired constitutive model for thrombus that considers a non-uniform distribution of microstructural fibers at various crimp levels and employs one of the distribution parameters to incorporate stretch-driven damage on the microscopic level. To demonstrate its ability to represent the mechanical behavior of thrombus, including a recently reported Mullins type damage phenomenon, we fit our model to uniaxial tensile test data of early venous thrombus. Our model shows an agreement with these data comparable to previous models for damage in elastomers with the added advantages of a microstructural basis and fewer model parameters. We submit that our novel approach marks another important step toward modeling the evolving mechanics of intraluminal thrombus, specifically its damage, and hope it will aid in the study of physiological and pathological thrombotic events.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.