Evidence map›Paper›PMID 26523693›Full record

ArticlePsychology and aging2015

Effects of education and race on cognitive decline: An integrative study of generalizability versus study-specific results.

Alden L Gross, Dan M Mungas, Paul K Crane, Laura E Gibbons, Anna MacKay-Brandt, Jennifer J Manly, Shubhabrata Mukherjee, Heather Romero, Bonnie Sachs, Michael Thomas and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Psychology and aging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 4 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 4 syntheses or guidelines pooled it, 126 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Article
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  10. Article
  11. Cognitive data harmonization across two racially diverse cohorts in the United States.Alzheimer's & dementia. Behavior & socioeconomics of aging · 2025
    Article
  12. Article
  13. Dynamic Regression of Longitudinal Trajectory Features.Journal of the American Statistical Association · 2025
    Article
  14. Article
  15. Cognitive decline and diabetes in the clinical setting.Medicine and pharmacy reports · 2025
    Article
  16. Article
  17. Social determinants of health but not global genetic ancestry predict dementia prevalence in Latin America.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  18. Unhealthy white matter connectivity, cognition, and racialization in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  19. Article
  20. Article

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alden L GrossDepartment of Epidemiology.
Dan M MungasDepartment of Psychiatry.
Paul K CraneDepartment of General Internal Medicine.
Laura E GibbonsDepartment of General Internal Medicine.
Anna MacKay-BrandtDepartment of Neurology.
Jennifer J ManlyTaub Institute for Research on Alzheimer's Disease and the Aging Brain.
Shubhabrata MukherjeeDepartment of General Internal Medicine.
Heather RomeroDepartment of Psychiatry and Behavioral Sciences.
Bonnie SachsDepartment of Neurology.
Michael ThomasDepartment of Psychiatry.
Guy G PotterDepartment of Psychiatry and Behavioral Sciences.
Richard N JonesDepartment of Psychiatry.ORCID 0000-0002-1049-218X

Funding

THERAPEUTIC EFFECTS OF INTRA-NASAL INSULIN DETEMIRP50AG005136 · NIA · UNIVERSITY OF WASHINGTON · PI JAYADEY, SUMAN · 1985 to 2019
$57.2M
'T V ASSESSMENT - MEMORY DISORDERED PATIENTS'P50AG005146 · NIA · JOHNS HOPKINS UNIVERSITY · PI ALBERT, MARILYN S. · 1985 to 2019
$37.6M
Recruitment and Assessment Core Patient RecruitmentP50MH060451 · NIMH · DUKE UNIVERSITY · PI MCCARTHY, GREGORY E · 2001 to 2010
$22.3M
Geriatric Depression: Risk Factors for Adverse OutcomesR01MH054846 · NIMH · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI STEFFENS, DAVID C. · 1995 to 2016
$10.1M
NEUROPATHOLOGY COREP30AG028377 · NIA · DUKE UNIVERSITY · PI WELSH-BOHMER, KATHLEEN ANNE · 2006 to 2011
$9.6M
Research Training in Late-Life NeuroPsychiatric DisordersT32MH020004 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Patrick J Brown · 1998 to 2026
$6.1M
INVESTIGATOR DEVELOPMENT COREP30AG043097 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HINTON, WALTER LADSON · 2012 to 2017
$2.9M
Anhedonia, Aging, and the Neural Correlates of Attentional Control in DepressionK23MH087741 · NIMH · DUKE UNIVERSITY · PI POTTER, GUY GLENN · 2010 to 2014
$680k
Conference on Advanced Psychometric Methods in Cognitive Aging ResearchR13AG030995 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MUNGAS, DAN M. · 2008 to 2022
$620k
CSHL Neurobiology of Drosophila CourseR13DA034437 · NIDA · COLD SPRING HARBOR LABORATORY · PI STEWART, DAVID J. · 2012 to 2016
$175k
Big Questions in Cognitive Aging: An Integrative Analysis ApproachR03AG045494 · NIA · JOHNS HOPKINS UNIVERSITY · PI GROSS, ALDEN L. · 2013 to 2013
$81k
CSHL 2015Cell Death ConferenceR13AG051368 · NIA · COLD SPRING HARBOR LABORATORY · PI STEWART, DAVID J. · 2015 to 2015
$15k
NIA NIH HHS P30 AG028377NIA NIH HHS P30 AG043097NIA NIH HHS P50 AG005136NIA NIH HHS P50 AG005146NIA NIH HHS P50 AG05136NIA NIH HHS R01 AG045494NIA NIH HHS R03 AG045494NIA NIH HHS R13 AG030995NIA NIH HHS R13 AG051368NIDA NIH HHS R13 DA034437NIMH NIH HHS K23 MH087741NIMH NIH HHS P50 MH060451NIMH NIH HHS R01 MH054846NIMH NIH HHS T32 MH020004NIMH NIH HHS T32MH20004
6 · The paper itself

Abstract

The objective of the study was to examine variability across multiple prospective cohort studies in level and rate of cognitive decline by race/ethnicity and years of education. We compare data across studies, we harmonized estimates of common latent factors representing overall or general cognitive performance, memory, and executive function derived from the: (a) Washington Heights, Hamilton Heights, Inwood Columbia Aging Project (N = 4,115), (b) Spanish and English Neuropsychological Assessment Scales (N = 525), (c) Duke Memory, Health, and Aging study (N = 578), and (d) Neurocognitive Outcomes of Depression in the Elderly (N = 585). We modeled cognitive change over age for cognitive outcomes by race, education, and study. We adjusted models for sex, dementia status, and study-specific characteristics. The results found that for baseline levels of overall cognitive performance, memory, and executive function, differences in race and education tended to be larger than between-study differences and consistent across studies. This pattern did not hold for rate of cognitive decline: effects of education and race/ethnicity on cognitive change were not consistently observed across studies, and when present were small, with racial/ethnic minorities and those with lower education declining at faster rates. In this diverse set of datasets, non-Hispanic Whites and those with higher education had substantially higher baseline cognitive test scores. However, differences in the rate of cognitive decline by race/ethnicity and education did not follow this pattern. This study suggests that baseline test scores and longitudinal change have different determinants, and future studies to examine similarities and differences of causes of cognitive decline in racially/ethnically and educationally diverse older groups is needed.

Indexed as

AgingEducational StatusNeuropsychological TestsAgedAged, 80 and overCognitionCognition DisordersEthnicityExecutive FunctionFemaleHispanic or LatinoHumansLanguageMaleMiddle AgedProspective Studies

Identifiers

PMID26523693
PMCPMC4679562
OpenAlexW2409094666

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.