ArticleNature neuroscience2015
Neuronal activity is not required for the initial formation and maturation of visual selectivity.
Article in Nature neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 64 citations in OpenAlex.
- Functional organization of dendritic spines in mouse visual cortex layer 2/3 neurons.iScience · 2026Article
- Interneuron and glial mechanisms underlying V1 orientation map dynamics.IBRO neuroscience reports · 2026Article
- CDKL5 deficiency results in atypical subregion-specific expression of perineuronal nets during mouse visual critical period.Frontiers in neuroscience · 2026Article
- Development and organization of the retinal orientation selectivity map.Nature communications · 2024Article
- Development of ocular dominance columns across rodents and other species: revisiting the concept of critical period plasticity.Frontiers in neural circuits · 2024Review
- Article
- Developmental stage-specific spontaneous activity contributes to callosal axon projections.eLife · 2022Article
- Emergence of probabilistic representation in the neural network of primary visual cortex.iScience · 2022Article
- Article
- Review
- The development of active binocular vision under normal and alternate rearing conditions.eLife · 2021Article
- Modeling the role of gap junctions between excitatory neurons in the developing visual cortex.PLoS computational biology · 2021Article
- Article
- Combinatorial Developmental Controls on Striatonigral Circuits.Cell reports · 2020Article
- Unsupervised experience with temporal continuity of the visual environment is causally involved in the development of V1 complex cells.Science advances · 2020Article
- Development and binocular matching of orientation selectivity in visual cortex: a computational model.Journal of neurophysiology · 2020Article
- Natural images are reliably represented by sparse and variable populations of neurons in visual cortex.Nature communications · 2020Article
- Experience-Dependent Development and Maintenance of Binocular Neurons in the Mouse Visual Cortex.Cell reports · 2020Article
- Single-Cell Visualization Deep in Brain Structures by Gene Transfer.Frontiers in neural circuits · 2020Article
- Characterisation of nonlinear receptive fields of visual neurons by convolutional neural network.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuronal activity is important for the functional refinement of neuronal circuits in the early visual system. At the level of the cerebral cortex, however, it is still unknown whether the formation of fundamental functions such as orientation selectivity depends on neuronal activity, as it has been difficult to suppress activity throughout development. Using genetic silencing of cortical activity starting before the formation of orientation selectivity, we found that the orientation selectivity of neurons in the mouse visual cortex formed and matured normally despite a strong suppression of both spontaneous and visually evoked activity throughout development. After the orientation selectivity formed, the distribution of the preferred orientations of neurons was reorganized. We found that this process required spontaneous activity, but not visually evoked activity. Thus, the initial formation and maturation of orientation selectivity is largely independent of neuronal activity, and the initial selectivity is subsequently modified depending on neuronal activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.