ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2016
Age and Ebola viral load correlate with mortality and survival time in 288 Ebola virus disease patients.
Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
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Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Clinical factors associated with mortality in ebola virus disease: a systematic review and meta-analysis.BMC infectious diseases · 2026Pooled it
- A systematic review and meta-analysis of patient data from the West Africa (2013-16) Ebola virus disease epidemic.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2019Pooled it
- Anti-Ebola Virus Antibody Levels in Convalescent Plasma and Viral Load After Plasma Infusion in Patients With Ebola Virus Disease.The Journal of infectious diseases · 2018Trial
- A Randomized, Controlled Trial of ZMapp for Ebola Virus Infection.The New England journal of medicine · 2016Trial
- Molecular Phenotypes of Sex- and Age-Specific Differences Relating to Outcome in Patients With Ebola Virus Disease.The Journal of infectious diseases · 2026Article
- Identification of Host Gene Transcripts by Machine Learning and Their Application to Predict Outcome in Ebola Virus Disease.The Journal of infectious diseases · 2026Article
- Host-virus association databases as tools for understanding viral spillover at varying scales.PLoS neglected tropical diseases · 2026Article
- A Framework for Assessing the Opportunity for Advanced Research, Development, and Regulatory Approval of Medical Countermeasures: A Component of BARDA's Emerging Infectious Diseases Strategy.The Journal of infectious diseases · 2026Article
- Mapping of susceptibility loci for Ebola virus pathogenesis in mice.Cell reports · 2024Article
- Heterogeneous SARS-CoV-2 kinetics due to variable timing and intensity of immune responses.JCI insight · 2024Article
- Heterogeneous SARS-CoV-2 kinetics due to variable timing and intensity of immune responses.medRxiv : the preprint server for health sciences · 2024Article
- Editorial: Community series - innovative approaches in diagnosis of emerging/re-emerging infectious diseases, volume II.Frontiers in microbiology · 2023Article
- High Levels of Antibiotic Resistance Patterns in Two Referral Hospitals during the Post-Ebola Era in Free-Town, Sierra Leone: 2017-2019.Tropical medicine and infectious disease · 2021Article
- Article
- Characterization of Ebola Virus Risk to Bedside Providers in an Intensive Care Environment.Microorganisms · 2021Article
- A flexible format LAMP assay for rapid detection of Ebola virus.PLoS neglected tropical diseases · 2020Article
- Immunologic timeline of Ebola virus disease and recovery in humans.JCI insight · 2020Article
- Pre-emptive genomic surveillance of emerging ebolaviruses.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2020Article
- Reproductive health sequelae among women who survived Ebola virus disease in Liberia.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2019Article
- Effectiveness of Dettol Antiseptic Liquid for Inactivation of Ebola Virus in Suspension.Scientific reports · 2019Article
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42 authors.
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Abstract
backgroundA Chinese medical team managed Ebola virus disease (EVD) patients in Sierra Leone from October 2014 to March 2015 and attended to 693 suspected patients, of whom 288 had confirmed disease.
methodsA retrospective study was conducted of the 288 patients with confirmed disease. Clinical symptoms, manifestations, and serum viral load were analyzed and compared among the different groups for mortality and survival time.
resultsAmong the 288 confirmed EVD patients (149 male and 139 female, median age 28 years, and median log viral load 6.68), 98 died, 36 recovered, and 154 were lost to follow-up. Common symptoms were fever (77.78%), fatigue (64.93%), abdominal pain (64.58%), headache (62.85%), and diarrhea (61.81%). Compared to patients aged<18 years, those who were older than 40 years had a higher probability of death (odds ratio 2.855, p=0.044). Patients with a viral load of >10(6) copies/ml had a higher case fatality rate than those with <10(6) copies/ml (odds ratio 3.095, p=0.004). Cox regression showed that age, viral load, and the presence of diarrhea correlated with mortality.
conclusionPatients with a high viral load, of older age, and with diarrhea had a higher mortality and shorter survival time.
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