Evidence map›Paper›PMID 26523525›Full record

Trial reportThe Journal of clinical endocrinology and metabolism2016

Omega-3 Fatty Acid Supplementation Lowers Serum FSH in Normal Weight But Not Obese Women.

Zain A Al-Safi, Huayu Liu, Nichole E Carlson, Justin Chosich, Mary Harris, Andrew P Bradford, Celeste Robledo, Robert H Eckel, Alex J Polotsky

Open access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of clinical endocrinology and metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Trial
  5. Evaluation of the role ofVeterinary and animal science · 2026
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  10. Oocyte and dietary supplements: a mini review.Frontiers in cell and developmental biology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Zain A Al-SafiDepartment of Obstetrics and Gynecology (Z.A.A., J.C., A.P.B., C.R., A.J.P.), University of Colorado School of Medicine, Aurora, Colorado 80045; Department of Biostatistics and Informatics (H.L., N.E.C.), Colorado School of Public Health, Aurora, Colorado 80045; Department of Food Science and Human Nutrition (M.H.), Colorado State University, Fort Collins, Colorado 80523; and Department of Medicine (R.H.E.), University of Colorado School of Medicine, Aurora, Colorado 80045.
Huayu LiuDepartment of Obstetrics and Gynecology (Z.A.A., J.C., A.P.B., C.R., A.J.P.), University of Colorado School of Medicine, Aurora, Colorado 80045; Department of Biostatistics and Informatics (H.L., N.E.C.), Colorado School of Public Health, Aurora, Colorado 80045; Department of Food Science and Human Nutrition (M.H.), Colorado State University, Fort Collins, Colorado 80523; and Department of Medicine (R.H.E.), University of Colorado School of Medicine, Aurora, Colorado 80045.
Nichole E CarlsonDepartment of Obstetrics and Gynecology (Z.A.A., J.C., A.P.B., C.R., A.J.P.), University of Colorado School of Medicine, Aurora, Colorado 80045; Department of Biostatistics and Informatics (H.L., N.E.C.), Colorado School of Public Health, Aurora, Colorado 80045; Department of Food Science and Human Nutrition (M.H.), Colorado State University, Fort Collins, Colorado 80523; and Department of Medicine (R.H.E.), University of Colorado School of Medicine, Aurora, Colorado 80045.
Justin ChosichDepartment of Obstetrics and Gynecology (Z.A.A., J.C., A.P.B., C.R., A.J.P.), University of Colorado School of Medicine, Aurora, Colorado 80045; Department of Biostatistics and Informatics (H.L., N.E.C.), Colorado School of Public Health, Aurora, Colorado 80045; Department of Food Science and Human Nutrition (M.H.), Colorado State University, Fort Collins, Colorado 80523; and Department of Medicine (R.H.E.), University of Colorado School of Medicine, Aurora, Colorado 80045.
Mary HarrisDepartment of Obstetrics and Gynecology (Z.A.A., J.C., A.P.B., C.R., A.J.P.), University of Colorado School of Medicine, Aurora, Colorado 80045; Department of Biostatistics and Informatics (H.L., N.E.C.), Colorado School of Public Health, Aurora, Colorado 80045; Department of Food Science and Human Nutrition (M.H.), Colorado State University, Fort Collins, Colorado 80523; and Department of Medicine (R.H.E.), University of Colorado School of Medicine, Aurora, Colorado 80045.
Andrew P BradfordDepartment of Obstetrics and Gynecology (Z.A.A., J.C., A.P.B., C.R., A.J.P.), University of Colorado School of Medicine, Aurora, Colorado 80045; Department of Biostatistics and Informatics (H.L., N.E.C.), Colorado School of Public Health, Aurora, Colorado 80045; Department of Food Science and Human Nutrition (M.H.), Colorado State University, Fort Collins, Colorado 80523; and Department of Medicine (R.H.E.), University of Colorado School of Medicine, Aurora, Colorado 80045.
Celeste RobledoDepartment of Obstetrics and Gynecology (Z.A.A., J.C., A.P.B., C.R., A.J.P.), University of Colorado School of Medicine, Aurora, Colorado 80045; Department of Biostatistics and Informatics (H.L., N.E.C.), Colorado School of Public Health, Aurora, Colorado 80045; Department of Food Science and Human Nutrition (M.H.), Colorado State University, Fort Collins, Colorado 80523; and Department of Medicine (R.H.E.), University of Colorado School of Medicine, Aurora, Colorado 80045.
Robert H EckelDepartment of Obstetrics and Gynecology (Z.A.A., J.C., A.P.B., C.R., A.J.P.), University of Colorado School of Medicine, Aurora, Colorado 80045; Department of Biostatistics and Informatics (H.L., N.E.C.), Colorado School of Public Health, Aurora, Colorado 80045; Department of Food Science and Human Nutrition (M.H.), Colorado State University, Fort Collins, Colorado 80523; and Department of Medicine (R.H.E.), University of Colorado School of Medicine, Aurora, Colorado 80045.
Alex J PolotskyDepartment of Obstetrics and Gynecology (Z.A.A., J.C., A.P.B., C.R., A.J.P.), University of Colorado School of Medicine, Aurora, Colorado 80045; Department of Biostatistics and Informatics (H.L., N.E.C.), Colorado School of Public Health, Aurora, Colorado 80045; Department of Food Science and Human Nutrition (M.H.), Colorado State University, Fort Collins, Colorado 80523; and Department of Medicine (R.H.E.), University of Colorado School of Medicine, Aurora, Colorado 80045.
University of Colorado Denver · USColorado School of Public Health · USColorado State University · US

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025780 · NCRR · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2008 to 2011
$61.3M
Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Wendy M Kohrt · 1995 to 2026
$32.6M
PROJECT 4 - Antagonistic Actions of Melanocortins and Leptin on Reproductive CompU54HD058155 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI POLLARD, JEFFREY W. · 2009 to 2013
$6.8M
NCATS NIH HHS UL1 TR001082NCRR NIH HHS 1UL1 RR025780NCRR NIH HHS UL1 RR025780NICHD NIH HHS U54 HD058155NICHD NIH HHS U54-HD058155
6 · The paper itself

Abstract

contextDietary omega-3 fatty acids delay ovarian aging and promote oocyte quality in mice.

objectiveTo test whether dietary supplementation with omega-3 polyunsaturated fatty acids (PUFA) modulates reproductive hormones in reproductive-age women.

designProspective interventional study.

settingAcademic center.

participantsFifteen obese and 12 normal-weight (NW) eumenorrheic women, ages 28-34 years.

interventionTwo frequent blood-sampling studies were performed before and after 1 month of omega-3 PUFA supplementation with 4 g of eicosapentaenoic acid and docosahexaenoic acid daily.

main outcome measuresSerum LH and FSH (basal and after GnRH stimulation).

resultsThe ratio of omega-6 to omega-3 PUFA was significantly reduced in plasma and red blood cell components for both groups after treatment (both P < .01). Omega-3 PUFA supplementation resulted in reduction of FSH and FSH response to GnRH by 17% on average (P = .06 and P = .03, respectively) in NW but not obese women. Serum levels of IL-1β and TNF-α were reduced after omega-3 PUFA supplementation (-72% for IL-1β; -56% for TNF-α; both, P < .05) in obese but not in NW women. This reduction, however, was not associated with a hormonal change in obese women.

conclusionsDietary administration with omega-3 PUFA decreased serum FSH levels in NW but not in obese women with normal ovarian reserve. This effect is intriguing and is directionally consistent with murine data whereby higher dietary omega-3 PUFA extends reproductive lifespan. Our results imply that this nutritional intervention should be tested in women with diminished ovarian reserve in an attempt to delay ovarian aging.

Indexed as

Dietary SupplementsAdultCytokinesFatty AcidsFatty Acids, Omega-3FemaleFollicle Stimulating HormoneGonadotropinsHumansInterleukin-1betaLuteinizing HormoneObesityOvaryPhospholipidsProspective StudiesTumor Necrosis Factor-alphaCytokinesFatty AcidsFatty Acids, Omega-3Follicle Stimulating HormoneGonadotropinsIL1B protein, humanInterleukin-1betaLuteinizing HormonePhospholipidsTumor Necrosis Factor-alpha

Identifiers

PMID26523525
PMCPMC4701838
OpenAlexW2109533285

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.