ArticleJournal of the American Chemical Society2015
Chemical Mutagenesis of an Emissive RNA Alphabet.
Article in Journal of the American Chemical Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed.
- Fluorescent cAMP Analogs: Enzymatic Synthesis, Unexpected Photophysical Behavior and Protein Kinase A Recognition.Angewandte Chemie (International ed. in English) · 2026Article
- Conformational landscape of 2-aminopurine-substituted RNA oligonucleotides from machine-learning-driven enhanced sampling.Physical chemistry chemical physics : PCCP · 2026Article
- Emissive Alkylated Guanine Analogs as Probes for MonitoringACS omega · 2024Article
- Emissive Guanosine Analog Applicable for Real-Time Live Cell Imaging.ACS chemical biology · 2024Article
- Site-specific RNA modificationRSC chemical biology · 2024Article
- Isomorphic Fluorescent Nucleosides.Accounts of chemical research · 2024Article
- Quantum-Chemistry Study of the Photophysical Properties of 4-Thiouracil and Comparisons with 2-Thiouracil.The journal of physical chemistry. A · 2024Article
- Inherently Emissive Puromycin Analogues for Live Cell Labelling.Angewandte Chemie (International ed. in English) · 2023Article
- Base-Stacking Heterogeneity in RNA Resolved by Fluorescence-Detected Circular Dichroism Spectroscopy.The journal of physical chemistry letters · 2022Article
- Isomorphic Fluorescent Nucleosides Facilitate Real-Time Monitoring of RNA Depurination by Ribosome Inactivating Proteins.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Affinity-Based Profiling of the Flavin Mononucleotide Riboswitch.Journal of the American Chemical Society · 2022Article
- Azetidines-Containing Fluorescent Purine Analogs: Synthesis and Photophysical Properties.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- A New Variant of Emissive RNA Alphabets.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- A Small Molecule Exploits Hidden Structural Features within the RNA Repeat Expansion That Causes c9ALS/FTD and Rescues Pathological Hallmarks.ACS chemical neuroscience · 2021Article
- Cytidine deaminase can deaminate fused pyrimidine ribonucleosides.Organic & biomolecular chemistry · 2021Article
- Real-Time Monitoring of Human Guanine Deaminase Activity by an Emissive Guanine Analog.ACS chemical biology · 2021Article
- Identification of Adenosine Deaminase Inhibitors by Metal-binding Pharmacophore Screening.ChemMedChem · 2020Article
- Tuning the Innate Immune Response to Cyclic Dinucleotides by Using Atomic Mutagenesis.Chembiochem : a European journal of chemical biology · 2020Article
- Enzymatic Syntheses and Applications of Fluorescent Cyclic Dinucleotides.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
- Flexibility and Preorganization of Fluorescent Nucleobase-Pyrene Conjugates Control DNA and RNA Recognition.Molecules (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
An evolved fluorescent ribonucleoside alphabet comprising isomorphic purine ((tz)A, (tz)G) and pyrimidine ((tz)U, (tz)C) analogues, all derived from isothiazolo[4,3-d]pyrimidine as a common heterocyclic core, is described. Structural and biochemical analyses illustrate that the nucleosides, particularly the C-nucleosidic purine analogues, are faithful isomorphic and isofunctional surrogates of their natural counterparts and show improved features when compared to an RNA alphabet derived from thieno[3,4-d]-pyrimidine. The restoration of the nitrogen in a position equivalent to the purines' N7 leads to "isofunctional" behavior, as illustrated by the ability of adenosine deaminase to deaminate (tz)A as effectively as adenosine, the native substrate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.