ArticleJournal of thyroid research2015
Cardiovascular Risk Factors in Subclinical Hypothyroidism: A Case Control Study in Nepalese Population.
Article in Journal of thyroid research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 35 citations in OpenAlex.
- The Relationship between Subclinical Hypothyroidism and Carotid Intima-Media Thickness as a Potential Marker of Cardiovascular Risk: A Systematic Review and a Meta-Analysis.Journal of cardiovascular development and disease · 2024Review
- Article
- A study of the cardiac risk factors emerging out of subclinical hypothyroidism.Journal of family medicine and primary care · 2019Article
- Age and Gender Specific Thyroid Hormones and Their Relationships with Body Mass Index in a Large Chinese Population.International journal of endocrinology and metabolism · 2019Article
- Association of high-sensitivity C-reactive protein and uric acid with the metabolic syndrome components.SpringerPlus · 2016Article
- Thyroid dysfunction in metabolic syndrome patients and its relationship with components of metabolic syndrome.Clinical diabetes and endocrinology · 2016Article
- Subclinical Hypothyroidism and Cardiac Risk: Lessons from a South Indian Population Study.Indian journal of endocrinology and metabolismArticle
- CORRELATION BETWEEN SUBCLINICAL HYPOTHYROIDISM AND DYSLIPIDEMIA IN WOMEN IN NORTHEAST CHINA.Acta endocrinologica (Bucharest, Romania : 2005)Article
- Levothyroxine improves Paraoxonase (PON-1) serum levels in patients with primary hypothyroidism: Case-control study.Journal of advanced pharmaceutical technology & researchArticle
- Thyroid Function Assessment in Saudi Males with Metabolic Syndrome.Journal of pharmacy & bioallied sciencesArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives. To assess cardiovascular risk factors in Nepalese population with subclinical hypothyroidism as compared to age and sex matched controls. Materials and Methods. A case control study was conducted among 200 subjects (100 subclinical hypothyroid and 100 euthyroid) at B.P. Koirala Institute of Health Sciences, Dharan, Nepal. Demographic and anthropometric variables including systolic and diastolic blood pressure (BP) were taken. Blood samples were assayed for serum free triiodothyronine (fT3), free thyroxine (fT4), thyroid stimulating hormone (TSH), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), and high sensitivity C reactive protein (hs-CRP). Results. Subclinical hypothyroid patients had significantly higher diastolic BP, total cholesterol, LDL cholesterol, and hs-CRP than controls. The odds ratio of having hypercholesterolemia (>200 mg/dL), low HDL cholesterol (<40 mg/dL), undesirable LDL-cholesterol (>100 mg/dL), high hs-CRP (>1 mg/L), and high diastolic BP (>80 mmHg) and being overweight (BMI ≥ 23 Kg/m(2)) in subclinical hypothyroidism was 2.29 (95% CI; 1.2-4.38, p = 0.011), 1.73 (95% CI; 0.82-3.62, p = 0.141), 3.04 (95% CI; 1.66-5.56, p < 0.001), 2.02 (95% CI; 1.12-3.64, p = 0.018), 3.35 (95% CI; 1.72-6.55, p < 0.001), and 0.9 (95% CI; 0.48-1.67, p = 0.753), respectively, as compared to controls. Conclusion. Subclinical hypothyroid patients are associated with higher risk for cardiovascular disease than euthyroid subjects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.