Evidence map›Paper›PMID 26523154›Full record

ArticleDiabetology & metabolic syndrome2015

Cost-effectiveness of a national population-based screening program for type 2 diabetes: the Brazil experience.

Cristiana M Toscano, Xiaohui Zhuo, Kumiko Imai, Bruce B Duncan, Carísi A Polanczyk, Ping Zhang, Michael Engelgau, Maria Inês Schmidt, CNDDM Working Group

Open access · goldAbstract read
In one paragraph

Article in Diabetology & metabolic syndrome, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Cristiana M ToscanoFederal University of Rio Grande do Sul, Porto Alegre, RS Brazil ; Federal University of Goiás (UFG), Rua T-62, 595, Apto. 201, Goiânia, GO 74223-180 Brazil.ORCID 0000-0002-9453-2643
Xiaohui ZhuoCenters for Disease Control and Prevention, Atlanta, GA USA.
Kumiko ImaiCenters for Disease Control and Prevention, Atlanta, GA USA ; UNICEF, New York City, New York USA.
Bruce B DuncanFederal University of Rio Grande do Sul, Porto Alegre, RS Brazil.
Carísi A PolanczykFederal University of Rio Grande do Sul, Porto Alegre, RS Brazil.
Ping ZhangCenters for Disease Control and Prevention, Atlanta, GA USA.
Michael EngelgauCenters for Disease Control and Prevention, Atlanta, GA USA ; National Institutes of Health, Bethesda, Maryland USA.
Maria Inês SchmidtFederal University of Rio Grande do Sul, Porto Alegre, RS Brazil.
CNDDM Working Group
Universidade Federal do Rio Grande do Sul · BRCenters for Disease Control and Prevention · USUnited Nations Children's Fund · USUnited States Department of Health and Human Services · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe cost-effectiveness of screening for type 2 diabetes mellitus (DM2) in developing countries remains unknown. The Brazilian government conducted a nationwide population screening program for type 2 diabetes mellitus (BNDSP) in which 22 million capillary glucose tests were performed in individuals aged 40 years and older. The objective of this study was to evaluate the life-time cost-effectiveness of a national population-based screening program for DM2 conducted in Brazil.

methodsWe used a Markov-based cost-effectiveness model to simulate the long-term costs and benefits of screening for DM2, compared to no screening program. The analysis was conducted from a public health care system perspective. Sensitivity analyses were conducted to examine the robustness of results to key model parameters.

resultsBrazilian National diabetes screening program will yield a large health benefit and higher costs. Compared with no screening, screen detection of undiagnosed diabetes resulted in US$ 31,147 per QALY gained. Results from sensitivity analyses found that screening targeted at hypertensive individuals would cost US$ 22,695/QALY. When benefits from early glycemic control on cardiovascular outcomes were considered, the cost per QALY gained would reduce significantly.

conclusionsIn the base case analysis, not considering the intangible benefit of transferring diabetes management to primary care nor the benefit of using statin to treat eligible diabetic patients, CE ratios were not cost-effective considering thresholds proposed by the World Health Organization. However, significant uncertainty was demonstrated in sensitivity analysis. Our results indicate that policy-makers should carefully balance the benefit and cost of the program while considering using a population-based approach to screen for diabetes.

Identifiers

PMID26523154
PMCPMC4628345
OpenAlexW1962638555

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.