Evidence map›Paper›PMID 26523102›Full record

ReviewWorld journal of gastroenterology2015

Arterial structure and function in inflammatory bowel disease.

Luca Zanoli, Stefania Rastelli, Gaetano Inserra, Pietro Castellino

Open access · hybridAbstract readReview
In one paragraph

Review in World journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 3 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 66 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Observational
  6. Article
  7. Review
  8. Review
  9. Residual Traditional Risk in Non-Traditional Atherosclerotic Diseases.International journal of molecular sciences · 2025
    Review
  10. Article
  11. Perivascular Adipose Tissue Becomes Pro-Contractile and Remodels in an IL10International journal of molecular sciences · 2024
    Article
  12. Review
  13. Article
  14. Review
  15. Coronary Artery Disease in CKD-G5D Patients: An Update.Reviews in cardiovascular medicine · 2023
    Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Luca ZanoliLuca Zanoli, Stefania Rastelli, Gaetano Inserra, Pietro Castellino, Department of Internal Medicine, Policlinico Universitario, University of Catania, 95123 Catania, Italy.
Stefania RastelliLuca Zanoli, Stefania Rastelli, Gaetano Inserra, Pietro Castellino, Department of Internal Medicine, Policlinico Universitario, University of Catania, 95123 Catania, Italy.
Gaetano InserraLuca Zanoli, Stefania Rastelli, Gaetano Inserra, Pietro Castellino, Department of Internal Medicine, Policlinico Universitario, University of Catania, 95123 Catania, Italy.
Pietro CastellinoLuca Zanoli, Stefania Rastelli, Gaetano Inserra, Pietro Castellino, Department of Internal Medicine, Policlinico Universitario, University of Catania, 95123 Catania, Italy.
Policlinico Universitario di Catania · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory bowel disease (IBD) is the result of a combination of environmental, genetic and immunologic factors that trigger an uncontrolled immune response within the intestine, which results in inflammation among genetically predisposed individuals. Several studies have reported that the prevalence of classic cardiovascular risk factors is lower among subjects with IBD than in the general population, including obesity, dyslipidaemia, diabetes and hypertension. Therefore, given the risk profile of IBD subjects, the expected cardiovascular morbidity and mortality should be lower in these patients than in the general population. However, this is not the case because the standardized mortality ratio is not reduced and the risk of coronary heart disease is increased in patients with IBD. It is reasonable to hypothesize that other factors not considered in the classical stratification of cardiovascular risk may be involved in these subjects. Therefore, IBD may be a useful model with which to evaluate the effects of chronic low-grade inflammation in the development of cardiovascular diseases. Arterial stiffness is both a marker of subclinical target organ damage and a cardiovascular risk factor. In diseases characterized by chronic systemic inflammation, there is evidence that the inflammation affects arterial properties and induces both endothelial dysfunction and arterial stiffening. It has been reported that decreasing inflammation via anti tumor necrosis factor alpha therapy decreases arterial stiffness and restores endothelial function in patients with chronic inflammatory disorders. Consistent with these results, several recent studies have been conducted to determine whether arterial properties are altered among patients with IBD. In this review, we discuss the evidence pertaining to arterial structure and function and present the available data regarding arterial stiffness and endothelial function in patients with IBD.

Indexed as

Vascular StiffnessArteriesCardiovascular DiseasesColitis, UlcerativeCrohn DiseaseHumansInflammation MediatorsRisk AssessmentRisk FactorsTumor Necrosis Factor-alphaInflammation MediatorsTumor Necrosis Factor-alphaArterial stiffnessCrohn’s diseaseInflammationPulse wave velocityTumour necrosis factor alphaUlcerative colitis

Identifiers

PMID26523102
PMCPMC4616206
OpenAlexW2418903567

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.