ArticleImmunity2015
Crossreactive αβ T Cell Receptors Are the Predominant Targets of Thymocyte Negative Selection.
Article in Immunity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
60 citing papers in PubMed, 82 citations in OpenAlex.
- Mucosal immunity: mechanism and application in cancer immunotherapy.Journal of hematology & oncology · 2026Review
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- A multidimensional toolkit for elucidating temporal trajectories in cell development in vivo.Development (Cambridge, England) · 2024Article
- The partitioning of TCR repertoires by thymic selection.The Journal of experimental medicine · 2024Review
- Human TCR repertoire in cancer.Cancer medicine · 2024Review
- Article
- Intraepithelial Lymphocytes of the Intestine.Annual review of immunology · 2024Review
- Gluten induces rapid reprogramming of natural memory αβ and γδ intraepithelial T cells to induce cytotoxicity in celiac disease.Science immunology · 2023Article
- Destined for the intestine: thymic selection of TCRαβ CD8αα intestinal intraepithelial lymphocytes.Clinical and experimental immunology · 2023Review
- A single-amino acid substitution in the adaptor LAT accelerates TCR proofreading kinetics and alters T-cell selection, maintenance and function.Nature immunology · 2023Article
- The endogenous repertoire harbors self-reactive CD4Nature immunology · 2023Article
- Genetic Strategies to Study T Cell Development.Methods in molecular biology (Clifton, N.J.) · 2023Article
- The promiscuous development of an unconventional Qa1b-restricted T cell population.Frontiers in immunology · 2023Article
- A Beginner's Guide to T Cell Development.Methods in molecular biology (Clifton, N.J.) · 2023Review
- The TCR Cα Domain Regulates Responses to Self-pMHC Class II.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Covalent TCR-peptide-MHC interactions induce T cell activation and redirect T cell fate in the thymus.Nature communications · 2022Article
- The perception and response of T cells to a changing environment are based on the law of initial value.Science signaling · 2022Review
- The transcription factor LRF promotes integrin β7 expression by and gut homing of CD8ααNature immunology · 2022Article
- Bcl-2 Is Necessary to Counteract Bim and Promote Survival of TCRαβJournal of immunology (Baltimore, Md. : 1950) · 2022Article
- How Thymocyte Deletion in the Cortex May Curtail Antigen-Specific T-Regulatory Cell Development in the Medulla.Frontiers in immunology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The precise impact of thymic positive and negative selection on the T cell receptor (TCR) repertoire remains controversial. Here, we used unbiased, high-throughput cloning and retroviral expression of individual pre-selection TCRs to provide a direct assessment of these processes at the clonal level in vivo. We found that 15% of random TCRs induced signaling and directed positive (7.5%) or negative (7.5%) selection, depending on strength of signal, whereas the remaining 85% failed to induce signaling or selection. Most negatively selected TCRs exhibited promiscuous crossreactivity toward multiple other major histocompatibility complex (MHC) haplotypes. In contrast, TCRs that were positively selected or non-selected were minimally crossreactive. Negative selection of crossreactive TCRs led to clonal deletion but also recycling into intestinal CD4(-)CD8β(-) intraepithelial lymphocytes (iIELs). Thus, broadly crossreactive TCRs arise at low frequency in the pre-selection repertoire but constitute the primary drivers of thymic negative selection and iIEL lineage differentiation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.