ArticleThe Journal of veterinary medical science2016
Canine pyometra: a model for the analysis of serum CXCL8 in inflammation.
Article in The Journal of veterinary medical science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 31 citations in OpenAlex.
- Retinal vascular calibers and correlations with biomarkers in bitches with pyometra-induced systemic inflammatory response syndrome.Veterinary world · 2025Article
- High-Sensitive Cardiac Troponin I and Th1/Th2 Polarization in Queens With Pyometra.Veterinary medicine and science · 2025Article
- Postoperative complications and antibiotic use in dogs with pyometra: a retrospective review of 140 cases (2019).Acta veterinaria Scandinavica · 2023Article
- Identification of Canine Pyometra-Associated Metabolites Using Untargeted Metabolomics.International journal of molecular sciences · 2022Article
- Exploring the mechanism of action of licorice in the treatment of COVID-19 through bioinformatics analysis and molecular dynamics simulation.Frontiers in pharmacology · 2022Article
- Tpl2 contributes to IL-1β-induced IL-8 expression via ERK1/2 activation in canine dermal fibroblasts.PloS one · 2021Article
- Endometritis in the bitch: Immunohistochemical localization of cyclooxygenase 2.Open veterinary journal · 2020Article
- Evaluation of cytokine concentrations in a trehalose-stabilised lyophilised canine platelet product: a preliminary study.Veterinary record open · 2020Article
- Cytokine and Chemokine Profiling in Cats With Sepsis and Septic Shock.Frontiers in veterinary science · 2020Article
- Regulation of inflammatory mediator expression in bovine endometrial cells: effects of lipopolysaccharide, interleukin 1 beta, and tumor necrosis factor alpha.Physiological reports · 2018Article
- Catalpol ameliorates LPS-induced endometritis by inhibiting inflammation and TLR4/NF-κB signaling.Journal of Zhejiang University. Science. BArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interleukin-8 (IL-8 or CXCL8) is a highly selective pro-inflammatory chemokine, that is elevated in sera of humans and animals with various inflammatory diseases. CXCL8 is possibly involved in uncontrolled inflammation and the development of a systemic inflammatory response syndrome (SIRS) and sepsis. Nevertheless, its behavior and precise properties in the course of inflammation are not fully understood. Thus, we used naturally occurring canine pyometra as a model of inflammation, in order to examine the behavior of serum CXCL8 in relation to the disease intensity and commonly analyzed inflammatory mediators. Using a commercially available canine ELISA kit, a significant increase of CXCL8 was determined in the serum of 23 dogs with pyometra compared with 35 healthy dogs. Interestingly, serum CXCL8 did not increase in severely diseased patients and behaved contrary to white blood cells (WBC), neutrophils and C-reactive protein (CRP). The measurement of serum CXCL8 may provide valuable information about the extent of ongoing lesions and could be a useful complement for existing laboratory tests.
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