ArticleAnnals of laboratory medicine2016
Comparison of automated treponemal and nontreponemal test algorithms as first-line syphilis screening assays.
Article in Annals of laboratory medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 31 citations in OpenAlex.
- Updates on epidemiology and diagnostic tests of syphilis in South Korea.The Korean journal of internal medicine · 2026Review
- Diagnostic Properties of Different Serological Methods for Syphilis Testing in Brazil.Diagnostics (Basel, Switzerland) · 2025Article
- Development of a novel magnetic particle-based agglutination immunoassay for anticardiolipin antibody detection in syphilis.Sexually transmitted infections · 2020Article
- Evaluating congenital syphilis in a reverse sequence testing environment.Journal of perinatology : official journal of the California Perinatal Association · 2019Article
- Urea-mediated dissociation alleviate the false-positive Treponema pallidum-specific antibodies detected by ELISA.PloS one · 2019Article
- Usefulness of Automated Latex Turbidimetric Rapid Plasma Reagin Test for Diagnosis and Evaluation of Treatment Response in Syphilis in Comparison with Manual Card Test: a Prospective Cohort Study.Journal of clinical microbiology · 2018Article
- Traditional versus reverse syphilis algorithms: A comparison at a large academic medical center.Practical laboratory medicine · 2017Article
- Evaluation of Elecsys Syphilis Assay for Routine and Blood Screening and Detection of Early Infection.Journal of clinical microbiology · 2016Article
- Traditional versus reverse algorithm for diagnosis of syphilis - An Indian perspective from a national referral laboratory for sexually transmitted infections.Indian journal of sexually transmitted diseases and AIDSArticle
- A Model for Syphilis Screening in the Emergency Department.Public health reports (Washington, D.C. : 1974)Article
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4 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundAutomated Mediace Treponema pallidum latex agglutination (TPLA) and Mediace rapid plasma reagin (RPR) assays are used by many laboratories for syphilis diagnosis. This study compared the results of the traditional syphilis screening algorithm and a reverse algorithm using automated Mediace RPR or Mediace TPLA as first-line screening assays in subjects undergoing a health checkup.
methodsSamples from 24,681 persons were included in this study. We routinely performed Mediace RPR and Mediace TPLA simultaneously. Results were analyzed according to both the traditional algorithm and reverse algorithm. Samples with discordant results on the reverse algorithm (e.g., positive Mediace TPLA, negative Mediace RPR) were tested with Treponema pallidum particle agglutination (TPPA).
resultsAmong the 24,681 samples, 30 (0.1%) were found positive by traditional screening, and 190 (0.8%) by reverse screening. The identified syphilis rate and overall false-positive rate according to the traditional algorithm were lower than those according to the reverse algorithm (0.07% and 0.05% vs. 0.64% and 0.13%, respectively). A total of 173 discordant samples were tested with TPPA by using the reverse algorithm, of which 140 (80.9%) were TPPA positive.
conclusionsDespite the increased false-positive results in populations with a low prevalence of syphilis, the reverse algorithm detected 140 samples with treponemal antibody that went undetected by the traditional algorithm. The reverse algorithm using Mediace TPLA as a screening test is more sensitive for the detection of syphilis.
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