Evidence map›Paper›PMID 26522752›Full record

ArticleAnnals of laboratory medicine2016

Immature platelet fraction in septic patients: clinical relevance of immature platelet fraction is limited to the sensitive and accurate discrimination of septic patients from non-septic patients, not to the discrimination of sepsis severity.

Sang Hyuk Park, Sang Ook Ha, Young Uk Cho, Chan Jeoung Park, Seongsoo Jang, Sang Bum Hong

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Article in Annals of laboratory medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

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10citing papers in PubMed
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1 · What the graph read from it

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10 citing papers in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Sang Hyuk ParkDepartment of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea.
Sang Ook HaDepartment of Emergency Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea.
Young Uk ChoDepartment of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea.
Chan Jeoung ParkDepartment of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea.
Seongsoo JangDepartment of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea. ssjang@amc.seoul.kr.
Sang Bum HongDepartment of Pulmonology and Critical Care Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea. sbhong@amc.seoul.kr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe immature platelet fraction (IPF) reflects the degree of reticulated platelets. We evaluated performances of IPF as a biomarker for the discrimination of septic patients from non-septic patients and sepsis severity.

methodsTotal 312 patients admitted between March and July 2013 were enrolled and samples were obtained at admission. Lactate (LA), procalcitonin (PCT), C-reactive protein (CRP), immature granulocyte fraction (IG), immature reticulocyte fraction (IRF), and IPF were analyzed as sepsis biomarkers and their performances were compared.

resultsThe performance of IPF (area under the curve [AUC]=0.868) in the discrimination of septic patients from non-septic patients was comparable to PCT/CRP/LA/IG (AUC=0.923/0.940/0.781/0.812, P=0.233/0.106/0.186/0.353, respectively), and was significantly better than the IRF (AUC=0.658, P=0.007). Sensitivity (89.8%, 95% confidence interval [CI] 84.9-99.8%) and accuracy (83.2%, 95% CI 78.8-90.0%) of IPF were the best among all biomarkers. The performance of IPF in discriminating septic patients from non-septic patients with local infection showed similar results. However, the IPF could not efficiently discriminate sepsis severity (AUC=0.599), similar to other biomarkers (AUC=0.519-0.752).

conclusionsThe IPF possessed high sensitivity/accuracy in discriminating septic patients from non-septic patients, regardless of local infection status. However, the IPF did not efficiently discriminate sepsis severity. The clinical relevance of IPF as a sepsis biomarker is, therefore, limited to sensitive and accurate discrimination of septic patients from non-septic patients, not discrimination of sepsis severity.

Indexed as

AdultAgedAged, 80 and overBiomarkersBlood PlateletsFemaleHumansMaleMiddle AgedReticulocytesSepsisYoung AdultBiomarkersBiomarkerDiscriminationImmature platelet fractionSepsisSeverity

Identifiers

PMID26522752
PMCPMC4697337

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