ArticlePhysiology & behavior2016
Hindbrain GLP-1 receptor mediation of cisplatin-induced anorexia and nausea.
Article in Physiology & behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 32 citations in OpenAlex.
- Intraperitoneal Injection of Cisplatin Induces Nausea-Like Responses without Vomiting in Chicks (The journal of poultry science · 2026Article
- Anatomical evidence links the stomach to the central amygdala, a region responsive to local GLP-1R agonist induced feeding and nausea-like behaviors in male mice.Frontiers in endocrinology · 2026Article
- Central mechanisms of emesis: A role for GDF15.Neurogastroenterology and motility · 2025Review
- Mechanisms and pharmacotherapy of cancer cachexia-associated anorexia.Pharmacology research & perspectives · 2025Review
- Glucagon-Like Peptide-1 Links Ingestion, Homeostasis, and the Heart.Comprehensive Physiology · 2025Review
- The antiemetic actions of GIP receptor agonism.American journal of physiology. Endocrinology and metabolism · 2024Review
- Novel Insights into the Physiology of Nutrient Sensing and Gut-Brain Communication in Surgical and Experimental Obesity Therapy.Obesity surgery · 2023Review
- Screening study of anti-emetics to improve GDF15-induced malaise and anorexia: Implications for emesis control.Physiology & behavior · 2023Article
- HypoMap-a unified single-cell gene expression atlas of the murine hypothalamus.Nature metabolism · 2022Article
- Brain GLP-1 and the regulation of food intake: GLP-1 action in the brain and its implications for GLP-1 receptor agonists in obesity treatment.British journal of pharmacology · 2022Review
- Camptothecin effectively treats obesity in mice through GDF15 induction.PLoS biology · 2022Article
- Divergent Effect of Central Incretin Receptors Inhibition in a Rat Model of Sporadic Alzheimer's Disease.International journal of molecular sciences · 2022Article
- Research Progress of Liujunzi Decoction in the Treatment of Tumor-Associated Anorexia.Drug design, development and therapy · 2022Review
- Olanzapine Administration Reduces Chemotherapy-Induced Nausea Behavior in Rats.Biological research for nursing · 2021Article
- Activation of PPG neurons following acute stressors differentially involves hindbrain serotonin in male rats.Neuropharmacology · 2021Article
- Chronic hindbrain administration of oxytocin elicits weight loss in male diet-induced obese mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Review
- Leptin receptor-expressing nucleus tractus solitarius neurons suppress food intake independently of GLP1 in mice.JCI insight · 2020Article
- Phasic dopamine responses to a food-predictive cue are suppressed by the glucagon-like peptide-1 receptor agonist Exendin-4.Physiology & behavior · 2020Article
- GDF15 Induces Anorexia through Nausea and Emesis.Cell metabolism · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
While chemotherapy-induced nausea and vomiting are clinically controlled in the acute (<24 h) phase following treatment, the anorexia, nausea, fatigue, and other illness-type behaviors during the delayed phase (>24 h) of chemotherapy are largely uncontrolled. As the hindbrain glucagon-like peptide-1 (GLP-1) system contributes to energy balance and mediates aversive and stressful stimuli, here we examine the hypothesis that hindbrain GLP-1 signaling mediates aspects of chemotherapy-induced nausea and reductions in feeding behavior in rats. Specifically, hindbrain GLP-1 receptor (GLP-1R) blockade, via 4th intracerebroventricular (ICV) exendin-(9-39) injections, attenuates the anorexia, body weight reduction, and pica (nausea-induced ingestion of kaolin clay) elicited by cisplatin chemotherapy during the delayed phase (48 h) of chemotherapy-induced nausea. Additionally, the present data provide evidence that the central GLP-1-producing preproglucagon neurons in the nucleus tractus solitarius (NTS) of the caudal brainstem are activated by cisplatin during the delayed phase of chemotherapy-induced nausea, as cisplatin led to a significant increase in c-Fos immunoreactivity in NTS GLP-1-immunoreactive neurons. These data support a growing body of literature suggesting that the central GLP-1 system may be a potential pharmaceutical target for adjunct anti-emetics used to treat the delayed-phase of nausea and emesis, anorexia, and body weight loss that accompany chemotherapy treatments.
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