ArticleThe New phytologist2016
RDM4 modulates cold stress resistance in Arabidopsis partially through the CBF-mediated pathway.
Article in The New phytologist, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 59 citations in OpenAlex.
- Article
- Temperature regulation in plants: From molecular mechanisms to climate-resilient crop improvement.Journal of integrative plant biology · 2026Review
- Integrated physiological, transcriptomic and metabolomic analysis reveals differential cold response in wheat seedlings across varieties.Frontiers in plant science · 2026Article
- Review
- Overexpression of aInternational journal of molecular sciences · 2025Article
- Overexpression of a Grape WRKY Transcription FactorInternational journal of molecular sciences · 2024Article
- Post-Translational Modifications in Histones and Their Role in Abiotic Stress Tolerance in Plants.Proteomes · 2023Review
- MdNAC104 positively regulates apple cold tolerance via CBF-dependent and CBF-independent pathways.Plant biotechnology journal · 2023Article
- The genome ofFrontiers in plant science · 2023Article
- The genetic basis of cold tolerance in cucumber (Cucumis sativus L.)-the latest developments and perspectives.Journal of applied genetics · 2022Review
- Molecular and Physiological Mechanisms to Mitigate Abiotic Stress Conditions in Plants.Life (Basel, Switzerland) · 2022Review
- Transcription-associated metabolomic profiling reveals the critical role of frost tolerance in wheat.BMC plant biology · 2022Article
- MYB-6 and LDOX-1 regulated accretion of anthocyanin response to cold stress in purple black carrot (Daucus carota L.).Molecular biology reports · 2022Article
- Physiological and Molecular Mechanism Involved in Cold Stress Tolerance in Plants.Plants (Basel, Switzerland) · 2020Review
- Identification of tissue-specific and cold-responsive lncRNAs in Medicago truncatula by high-throughput RNA sequencing.BMC plant biology · 2020Article
- Root Skewing-Associated Genes Impact the Spaceflight Response ofFrontiers in plant science · 2020Article
- Small DNA Methylation, Big Player in Plant Abiotic Stress Responses and Memory.Frontiers in plant science · 2020Review
- A Role for PICKLE in the Regulation of Cold and Salt Stress Tolerance in Arabidopsis.Frontiers in plant science · 2019Article
- Chilling-induced DNA Demethylation is associated with the cold tolerance of Hevea brasiliensis.BMC plant biology · 2018Article
- Stress-responsive gene RsICE1 from Raphanus sativus increases cold tolerance in rice.Protoplasma · 2017Article
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Authors and funding
10 authors at 8 institutions in 2 countries.
Funding
Abstract
The C-REPEAT-BINDING FACTOR (CBF) pathway has important roles in plant responses to cold stress. How the CBF genes themselves are activated after cold acclimation remains poorly understood. In this study, we characterized cold tolerance of null mutant of RNA-DIRECTED DNA METHYLATION 4 (RDM4), which encodes a protein that associates with RNA polymerases Pol V and Pol II, and is required for RNA-directed DNA methylation (RdDM) in Arabidopsis. The results showed that dysfunction of RDM4 reduced cold tolerance, as evidenced by decreased survival and increased electrolyte leakage. Mutation of RDM4 resulted in extensive transcriptomic reprogramming. CBFs and CBF regulon genes were down-regulated in rdm4 but not nrpe1 (the largest subunit of PolV) mutants, suggesting that the role of RDM4 in cold stress responses is independent of the RdDM pathway. Overexpression of RDM4 constitutively increased the expression of CBFs and regulon genes and decreased cold-induced membrane injury. A great proportion of genes affected by rdm4 overlapped with those affected by CBFs. Chromatin immunoprecipitation results suggested that RDM4 is important for Pol II occupancy at the promoters of CBF2 and CBF3. We present evidence of a considerable role for RDM4 in regulating gene expression at low temperature, including the CBF pathway in Arabidopsis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.