Evidence map›Paper›PMID 26522621›Full record

ArticleJournal of biomechanics2015

CEINMS: A toolbox to investigate the influence of different neural control solutions on the prediction of muscle excitation and joint moments during dynamic motor tasks.

Claudio Pizzolato, David G Lloyd, Massimo Sartori, Elena Ceseracciu, Thor F Besier, Benjamin J Fregly, Monica Reggiani

Registry-linked trialAbstract read
In one paragraph

Article in Journal of biomechanics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04778852 (Quantitative Assessment of Training Effects Using a Wearable Exoskeleton in Parkinson Disease Patients), which is not on this map. Cited by 110 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04778852 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Quantitative Assessment of Training Effects Using a Wearable Exoskeleton in Parkinson Disease Patients

TypeinterventionalSponsorUniversity of PadovaRan2020 to 2023Enrolled50ConditionsParkinson DiseaseArmsExperimental: EksoGT, Functional kinematic training
3 · Its place in the literature

Who cites it

110 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  8. Estimating Muscle Parameters via Hierarchical Bayesian Neuromechanics.bioRxiv : the preprint server for biology · 2026
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  10. Joint Reaction Forces Decrease Following Total Knee Arthroplasty up to 12-Months Post-Surgery.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
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  17. Benchmarking Neural Network Personalized Musculoskeletal Hand Models Against Current Personalization Standards Using Experimental Magnetic Resonance Imaging and Fine-Wire Electromyography.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026
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50 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Claudio PizzolatoCentre for Musculoskeletal Research, Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia.
David G LloydCentre for Musculoskeletal Research, Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia. Electronic address: david.lloyd@griffith.edu.au.
Massimo SartoriDepartment of Neurorehabilitation Engineering, University Medical Center Göttingen, Georg-August University, Göttingen, Germany.
Elena CeseracciuDepartment of Management and Engineering, University of Padua, Vicenza, Italy.
Thor F BesierAuckland Bioengineering Institute & Dept of Engineering Science, University of Auckland, Auckland, New Zealand.
Benjamin J FreglyDepartment of Mechanical and Aerospace Engineering, University of Florida, Gainesville, FL, USA.
Monica ReggianiDepartment of Management and Engineering, University of Padua, Vicenza, Italy. Electronic address: monica.reggiani@unipd.it.

Funding

Evaluation of In Vivo Knee Load Predictions using Instrumented ImplantsR01EB009351 · NIBIB · UNIVERSITY OF FLORIDA · PI D'LIMA, DARRYL D., FREGLY, BENJAMIN J · 2010 to 2013
$2.1M
NIBIB NIH HHS R01 EB009351NIBIB NIH HHS R01EB009351
6 · The paper itself

Abstract

Personalized neuromusculoskeletal (NMS) models can represent the neurological, physiological, and anatomical characteristics of an individual and can be used to estimate the forces generated inside the human body. Currently, publicly available software to calculate muscle forces are restricted to static and dynamic optimisation methods, or limited to isometric tasks only. We have created and made freely available for the research community the Calibrated EMG-Informed NMS Modelling Toolbox (CEINMS), an OpenSim plug-in that enables investigators to predict different neural control solutions for the same musculoskeletal geometry and measured movements. CEINMS comprises EMG-driven and EMG-informed algorithms that have been previously published and tested. It operates on dynamic skeletal models possessing any number of degrees of freedom and musculotendon units and can be calibrated to the individual to predict measured joint moments and EMG patterns. In this paper we describe the components of CEINMS and its integration with OpenSim. We then analyse how EMG-driven, EMG-assisted, and static optimisation neural control solutions affect the estimated joint moments, muscle forces, and muscle excitations, including muscle co-contraction.

Indexed as

ElectromyographyExcitation Contraction CouplingModels, BiologicalAlgorithmsComputer SimulationHumansJointsMovementMuscle ContractionMuscle, SkeletalEMG-drivenEMG-informedNeuromusculoskeletal modellingStatic optimisation

Identifiers

PMID26522621
PMCPMC4655131

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.