Evidence map›Paper›PMID 26522092›Full record

ReviewPreventive medicine2015

From fatalism to mitigation: A conceptual framework for mitigating fetal programming of chronic disease by maternal obesity.

Janne Boone-Heinonen, Lynne C Messer, Stephen P Fortmann, Lawrence Wallack, Kent L Thornburg

Open access · greenAbstract readReview
In one paragraph

Review in Preventive medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Janne Boone-HeinonenSchool of Public Health, Oregon Health & Science University, Portland, OR, USA. Electronic address: boonej@ohsu.edu.
Lynne C MesserSchool of Community Health, College of Urban and Public Affairs, Portland State University, Portland, OR, USA.
Stephen P FortmannKaiser Permanente Center for Health Research, Portland, OR, USA.
Lawrence WallackSchool of Community Health, College of Urban and Public Affairs, Portland State University, Portland, OR, USA.
Kent L ThornburgBob and Charlee Moore Institute for Nutrition and Wellness, Oregon Health & Science University, Portland, OR, USA.
Oregon Health & Science University · USPortland State University · USKaiser Permanente Center for Health Research · US

Funding

ULTRASOUND IMAGING COREP01HD034430 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI THORNBURG, KENT L.R. · 1997 to 2017
$20.7M
Scholars in Women's Health Research Across the LifespanK12HD043488 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI MYATT, LESLIE · 2002 to 2023
$10.4M
NICHD NIH HHS K12 HD043488NICHD NIH HHS K12HD043488-01NICHD NIH HHS P01 HD034430
6 · The paper itself

Abstract

Prenatal development is recognized as a critical period in the etiology of obesity and cardiometabolic disease. Potential strategies to reduce maternal obesity-induced risk later in life have been largely overlooked. In this paper, we first propose a conceptual framework for the role of public health and preventive medicine in mitigating the effects of fetal programming. Second, we review a small but growing body of research (through August 2015) that examines interactive effects of maternal obesity and two public health foci - diet and physical activity - in the offspring. Results of the review support the hypothesis that diet and physical activity after early life can attenuate disease susceptibility induced by maternal obesity, but human evidence is scant. Based on the review, we identify major gaps relevant for prevention research, such as characterizing the type and dose response of dietary and physical activity exposures that modify the adverse effects of maternal obesity in the offspring. Third, we discuss potential implications of interactions between maternal obesity and postnatal dietary and physical activity exposures for interventions to mitigate maternal obesity-induced risk among children. Our conceptual framework, evidence review, and future research directions offer a platform to develop, test, and implement fetal programming mitigation strategies for the current and future generations of children.

Indexed as

Fetal DevelopmentPregnancy ComplicationsPrenatal Exposure Delayed EffectsAnimalsChildChronic DiseaseDietDisease Models, AnimalExerciseFemaleHumansModels, BiologicalObesityPregnancyNutritionObesityPhysical activityPrenatal exposure delayed effectsPreventionSecond hit

Identifiers

PMID26522092
PMCPMC4679670
OpenAlexW1819326944

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.