ArticleScientific reports2015
Knockout crickets for the study of learning and memory: Dopamine receptor Dop1 mediates aversive but not appetitive reinforcement in crickets.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Transferable approaches to CRISPR-Cas9 induced genome editing in non-model insects: a brief guide.Frontiers in zoology · 2025Review
- Visuo-spatial compound stimuli discrimination with (Gryllus pennsylvanicus) in two-choices rewarding learning tasks.Animal cognition · 2024Article
- Independent operations of appetitive and aversive conditioning systems lead to simultaneous production of conflicting memories in an insect.Proceedings. Biological sciences · 2024Article
- Critical roles of nicotinic acetylcholine receptors in olfactory memory formation and retrieval in crickets.Frontiers in physiology · 2024Article
- MicroRNA ame-let-7 targets Amdop2 to increase sucrose sensitivity in honey bees (Apis mellifera).Frontiers in zoology · 2023Article
- Unveiling the Genetic Symphony: Harnessing CRISPR-Cas Genome Editing for Effective Insect Pest Management.Plants (Basel, Switzerland) · 2023Review
- Article
- Spontaneous recovery from overexpectation in an insect.Scientific reports · 2022Article
- Conditioned taste aversion in the cricket Gryllus bimaculatus.Scientific reports · 2022Article
- Cas9-mediated gene editing in the black-legged tick,iScience · 2022Article
- Dissecting cricket genomes for the advancement of entomology and entomophagy.Biophysical reviews · 2022Review
- Dopamine adjusts the circadian gene expression of Per2 and Per3 in human dermal fibroblasts from ADHD patients.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- What Is Learned in Pavlovian Conditioning in Crickets? Revisiting the S-S and S-R Learning Theories.Frontiers in behavioral neuroscience · 2021Review
- Transcriptome analysis of life stages of the house cricket, Acheta domesticus, to improve insect crop production.Scientific reports · 2020Article
- Adult neurogenesis in the mushroom bodies of red flour beetles (Tribolium castaneum, HERBST) is influenced by the olfactory environment.Scientific reports · 2020Article
- Injecting Gryllus bimaculatus Eggs.Journal of visualized experiments : JoVE · 2019Article
- Development of behavioural automaticity by extended Pavlovian training in an insect.Proceedings. Biological sciences · 2019Article
- Dop1 enhances conspecific olfactory attraction by inhibiting miR-9a maturation in locusts.Nature communications · 2018Article
- Stem cells and genome editing: approaches to tissue regeneration and regenerative medicine.Journal of human genetics · 2018Review
- Article
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6 authors.
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Abstract
Elucidation of reinforcement mechanisms in associative learning is an important subject in neuroscience. In mammals, dopamine neurons are thought to play critical roles in mediating both appetitive and aversive reinforcement. Our pharmacological studies suggested that octopamine and dopamine neurons mediate reward and punishment, respectively, in crickets, but recent studies in fruit-flies concluded that dopamine neurons mediates both reward and punishment, via the type 1 dopamine receptor Dop1. To resolve the discrepancy between studies in different insect species, we produced Dop1 knockout crickets using the CRISPR/Cas9 system and found that they are defective in aversive learning with sodium chloride punishment but not appetitive learning with water or sucrose reward. The results suggest that dopamine and octopamine neurons mediate aversive and appetitive reinforcement, respectively, in crickets. We suggest unexpected diversity in neurotransmitters mediating appetitive reinforcement between crickets and fruit-flies, although the neurotransmitter mediating aversive reinforcement is conserved. This study demonstrates usefulness of the CRISPR/Cas9 system for producing knockout animals for the study of learning and memory.
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