Evidence map›Paper›PMID 26521947›Full record

ArticleScientific reports2015

Inhibition of tribbles protein-1 attenuates radioresistance in human glioma cells.

Bo Tang, Wei Wu, Qing Zhang, Yongjin Sun, Yifen Cui, Fei Wu, Xiaowei Wei, Guangying Qi, Xingsi Liang, Fang Tang and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
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  10. Histone deacetylase inhibitor MPT0B291 suppresses Glioma GrowthInternational journal of biological sciences · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Bo TangDepartment of Hepatobiliary Surgery, Guilin Medical University, Affiliated Hospital, and Laboratory of Liver Injury and Repair Molecular Medicine, Guilin Medical University, Guilin, 541001, China.
Wei WuDepartment of Neurosurgery, The First Hospital of Jilin University, Changchun, 130021, China.
Qing ZhangAffiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.
Yongjin SunAffiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.
Yifen CuiAffiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.
Fei WuAffiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.
Xiaowei WeiAffiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.
Guangying QiDepartment of Hepatobiliary Surgery, Guilin Medical University, Affiliated Hospital, and Laboratory of Liver Injury and Repair Molecular Medicine, Guilin Medical University, Guilin, 541001, China.
Xingsi LiangDepartment of Hepatobiliary Surgery, Guilin Medical University, Affiliated Hospital, and Laboratory of Liver Injury and Repair Molecular Medicine, Guilin Medical University, Guilin, 541001, China.
Fang TangDepartment of Hepatobiliary Surgery, Guilin Medical University, Affiliated Hospital, and Laboratory of Liver Injury and Repair Molecular Medicine, Guilin Medical University, Guilin, 541001, China.
Yunqian LiDepartment of Neurosurgery, The First Hospital of Jilin University, Changchun, 130021, China.
Wenhai FanAffiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.
Affiliated Zhongshan Hospital of Dalian University · CNDalian University of Technology · CNFirst Hospital of Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiotherapy is one of the remedies in the treatment of glioma. The radioresistance is a major drawback, of which the mechanism is unclear. Tribble protein and histone deacetylase are involved in the cancer pathogenesis. This study aims to test a hypothesis that the histone deacetylase inhibitors attenuate the radioresistance in human glioma cells. In this study, human glioma cells were cultured. The cells were treated with irradiation with or without a histone deacetylase inhibitor, butyrate. Apoptosis of the glioma cells was assessed by flow cytometry. The results showed that human glioma cells expressed a low level of Trib1, which was significantly up regulated by exposure to small doses (2 Gy/day for 4 days) of irradiation. Trib1-deficient glioma cells showed an enhanced response to irradiation-induced apoptosis. Exposure to small doses of irradiation, Trib1 formed a complex with pHDAC1 (phosphor histone deacetylase-1) to inhibit p53 expression in glioma cells. The presence of HDAC1 inhibitor, butyrate or parthenolide, significantly enforced irradiation-induced glioma cell apoptosis. In conclusion, the Trib1 plays a critical role in the development of radioresistance of glioma cells. The data suggest that inhibition of Trib1 or HDAC1 has the potential to prevent or attenuate the radioresistance.

Indexed as

ApoptosisBrain NeoplasmsCell Line, TumorGene Expression Regulation, NeoplasticGliomaHistone Deacetylase 1Histone Deacetylase InhibitorsHumansIntracellular Signaling Peptides and ProteinsProtein Serine-Threonine KinasesRadiation ToleranceTumor Suppressor Protein p53Up-RegulationHDAC1 protein, humanHistone Deacetylase 1Histone Deacetylase InhibitorsIntracellular Signaling Peptides and ProteinsProtein Serine-Threonine KinasesTRIB1 protein, humanTumor Suppressor Protein p53

Identifiers

PMID26521947
PMCPMC4629151
OpenAlexW1926163647

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.