Evidence map›Paper›PMID 26521728›Full record

ReviewOsteoarthritis and cartilage2015

Inflammation in joint injury and post-traumatic osteoarthritis.

J Lieberthal, N Sambamurthy, C R Scanzello

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Osteoarthritis and cartilage, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 263 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
263citing papers in PubMed, 4 pooled it
9.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

263 citing papers in PubMed, 4 syntheses or guidelines pooled it, 501 citations in OpenAlex.

  1. Pooled it
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  11. Review
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  14. Novel Biomaterial-Based Synovial Fluid Analysis Reveals Protective microRNA Signatures in a Mouse Model of Acute Synovitis-Driven Osteoarthritis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  15. Article
  16. Review
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  20. Recombinant Human Amelogenin Protein Enhances Healing of Osteochondral Injury in a Goat Model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
    Article

203 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

J LieberthalUniversity of Pennsylvania Perelman School of Medicine, Division of Rheumatology, Philadelphia, PA, USA. Electronic address: jasonlieberthal@gmail.com.
N SambamurthyUniversity of Pennsylvania Perelman School of Medicine, Division of Rheumatology, Philadelphia, PA, USA. Electronic address: nishasam@mail.med.upenn.edu.
C R ScanzelloUniversity of Pennsylvania Perelman School of Medicine, Division of Rheumatology, Philadelphia, PA, USA; Translational Musculoskeletal Research Center, Corporal Michael J. Crescenz Department of Veterans Affairs Medical Center, Philadelphia, PA, USA. Electronic address: cscanz@upenn.edu.
University of Pennsylvania · US

Funding

The Toll-like receptor pathway in Meniscal Injury and OsteoarthritisK08AR057859 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI SCANZELLO, CARLA ROSE · 2010 to 2014
$620k
CCR7 and its ligands in OsteoarthritisR21AR067916 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI SCANZELLO, CARLA ROSE · 2015 to 2016
$387k
NIAMS NIH HHS K08 AR057859NIAMS NIH HHS K08AR057859NIAMS NIH HHS R21 AR067916NIAMS NIH HHS R21-AR-067916-01
6 · The paper itself

Abstract

Inflammation is a variable feature of osteoarthritis (OA), associated with joint symptoms and progression of disease. Signs of inflammation can be observed in joint fluids and tissues from patients with joint injuries at risk for development of post-traumatic osteoarthritis (PTOA). Furthermore, inflammatory mechanisms are hypothesized to contribute to the risk of OA development and progression after injury. Animal models of PTOA have been instrumental in understanding factors and mechanisms involved in chronic progressive cartilage degradation observed after a predisposing injury. Specific aspects of inflammation observed in humans, including cytokine and chemokine production, synovial reaction, cellular infiltration and inflammatory pathway activation, are also observed in models of PTOA. Many of these models are now being utilized to understand the impact of post-injury inflammatory response on PTOA development and progression, including risk of progressive cartilage degeneration and development of chronic symptoms post-injury. As evidenced from these models, a vigorous inflammatory response occurs very early after joint injury but is then sustained at a lower level at the later phases. This early inflammatory response contributes to the development of PTOA features including cartilage erosion and is potentially modifiable, but specific mediators may also play a role in tissue repair. Although the optimal approach and timing of anti-inflammatory interventions after joint injury are yet to be determined, this body of work should provide hope for the future of disease modification tin PTOA.

Indexed as

AnimalsCartilage, ArticularDisease ProgressionHumansInflammationInflammation MediatorsJointsOsteoarthritisWounds and InjuriesInflammation MediatorsChemokinesCytokinesInflammationJoint injuryOsteoarthritisPost-traumatic arthritis

Identifiers

PMID26521728
PMCPMC4630675
OpenAlexW1848620583

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.