Trial reportThe Journal of urology2016
First in Human Clinical Trial of Ultrasonic Propulsion of Kidney Stones.
Trial report in The Journal of urology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Safety and Effectiveness of the Ultrasonic Propulsion of Kidney Stones
Ultrasound Technology to Fragment and Reposition Urinary Stones
Who cites it
41 citing papers in PubMed, 66 citations in OpenAlex.
- Randomized Controlled Trial of Ultrasonic Propulsion-Facilitated Clearance of Residual Kidney Stone Fragments vs Observation.The Journal of urology · 2024Trial
- Break Wave Lithotripsy for Urolithiasis: Results of the First-in-Human International Multi-Institutional Clinical Trial.The Journal of urology · 2024Trial
- Improving Burst Wave Lithotripsy Effectiveness for Small Stones and Fragments by Increasing Frequency: Theoretical Modeling andJournal of endourology · 2022Trial
- First In-Human Burst Wave Lithotripsy for Kidney Stone Comminution: Initial Two Case Studies.Journal of endourology · 2021Trial
- Impact of Therapeutic Ultrasound on Metabolic Hormone Release From Thyroid Gland.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026Article
- Facilitated Clearance of Small, Asymptomatic Renal Stones With Burst Wave Lithotripsy and Ultrasonic Propulsion.The Journal of urology · 2025Article
- Overview of Therapeutic Ultrasound Applications and Safety Considerations: 2024 Update.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025Review
- Application of ultrasound imaging in the treatment of urinary tract stones.Journal of medical ultrasonics (2001) · 2023Review
- A magnetic hydrogel for the efficient retrieval of kidney stone fragments during ureteroscopy.Nature communications · 2023Article
- First Series Using Ultrasonic Propulsion and Burst Wave Lithotripsy to Treat Ureteral Stones.The Journal of urology · 2022Article
- Clinical application of the therapeutic ultrasound in urologic disease: Part II of therapeutic ultrasound in urology.Investigative and clinical urology · 2022Review
- Fragmentation of Stones by Burst Wave Lithotripsy in the First 19 Humans.The Journal of urology · 2022Article
- Recent Advances in the Science of Burst Wave Lithotripsy and Ultrasonic Propulsion.BME frontiers · 2022Article
- Minimally Invasive Surgery for the Treatment of Ureteric Stones - State-of-the-Art Review.Research and reports in urology · 2021Review
- Article
- Noninvasive acoustic manipulation of objects in a living body.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Pearl-unjammed: the Seattle stone maneuver for ureteropelvic junction urolithiasis.Journal of the American College of Emergency Physicians open · 2020Article
- In-Office Ultrasound Facilitates Timely Clinical Care at a Multidisciplinary Kidney Stone Center.Urology practice · 2020Article
- Fragmentation of brittle material by shock wave lithotripsy. Momentum transfer and inertia: a novel view on fragmentation mechanisms.Urolithiasis · 2020Article
- Burst wave lithotripsy and acoustic manipulation of stones.Current opinion in urology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
purposeUltrasonic propulsion is a new technology using focused ultrasound energy applied transcutaneously to reposition kidney stones. We report what are to our knowledge the findings from the first human investigational trial of ultrasonic propulsion toward the applications of expelling small stones and dislodging large obstructing stones. MATERIALS AND
methodsSubjects underwent ultrasonic propulsion while awake without sedation in clinic, or during ureteroscopy while anesthetized. Ultrasound and a pain questionnaire were completed before, during and after propulsion. The primary outcome was to reposition stones in the collecting system. Secondary outcomes included safety, controllable movement of stones and movement of stones less than 5 mm and 5 mm or greater. Adverse events were assessed weekly for 3 weeks.
resultsKidney stones were repositioned in 14 of 15 subjects. Of the 43 targets 28 (65%) showed some level of movement while 13 (30%) were displaced greater than 3 mm to a new location. Discomfort during the procedure was rare, mild, brief and self-limited. Stones were moved in a controlled direction with more than 30 fragments passed by 4 of the 6 subjects who had previously undergone a lithotripsy procedure. The largest stone moved was 10 mm. One patient experienced pain relief during treatment of a large stone at the ureteropelvic junction. In 4 subjects a seemingly large stone was determined to be a cluster of small passable stones after they were moved.
conclusionsUltrasonic propulsion was able to successfully reposition stones and facilitate the passage of fragments in humans. No adverse events were associated with the investigational procedure.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.