Evidence map›Paper›PMID 26521239›Full record

ReviewCurrent cardiology reports2015

New Developments in the Genetics of Hypertension: What Should Clinicians Know?

David S Geller

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current cardiology reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

David S GellerSection of Nephrology, Department of Medicine, Yale University School of Medicine, 330 Cedar Street, PO Box 208029, New Haven, CT, 06520-8029, USA. david.geller@yale.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It has long been known that genetic factors play a major role in determining an individual's propensity to hypertension. In recent years, there has been major progress towards realizing the goal of identifying the specific genetic factors that lead to alterations in blood pressure. Of particular note, new genes regulating renal sodium handling and aldosterone regulation have been discovered via the study of rare Mendelian disorders. Similarly, a number of large genome-wide association studies have been completed, which have added to our understanding as well. Here, recent progress in the genetics of hypertension will be reviewed, with an emphasis towards highlighting specific areas where clinical practice has already or will soon be affected.

Indexed as

Genome-Wide Association StudyChromosome MappingDNA Mutational AnalysisEvidence-Based MedicineGenetic LinkageGenotypeHumansHypertensionPhenotypePolymorphism, Single NucleotideGeneticsGenome-wide association studiesHypertensionHypertension with brachydactyly type EHypertension with hyperkalemiaPrimary aldosteronism

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.