ArticleJournal of endodontics2015
Microbiomes of Endodontic-Periodontal Lesions before and after Chemomechanical Preparation.
Article in Journal of endodontics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
90 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prevalence of species of yellow, purple and green microbial complexes in endo-perio lesions: a systematic review.Brazilian oral research · 2024Pooled it
- Prevalence of red and orange microbial complexes in endodontic-periodontal lesions: a systematic review and meta-analysis.Clinical oral investigations · 2021Pooled it
- Effectiveness of calcium hydroxide-based intracanal medication on infectious/inflammatory contents in teeth with post-treatment apical periodontitis.Clinical oral investigations · 2019Trial
- Sulfur metabolism and immune-microbial networks across oral niches in periodontal disease.Microbiology spectrum · 2026Article
- Association Between the Root Canal Microbiome and Apical Lesion Size: An Observational Shotgun Metagenomic Study.International endodontic journal · 2026Observational
- From Caries to Periodontal Breakdown: A Biological and Clinical Continuum Linking Cariology, Operative Dentistry, Endodontics, and Periodontology.Dentistry journal · 2026Review
- Histopathology, Diagnosis, Management and Treatment Outcomes of Cemental Tears: A Retrospective Observational Cohort Study.International endodontic journal · 2026Observational
- Is apical periodontitis a matter of microbial diversity or time? A scoping review.Head & face medicine · 2026Article
- Profiling of microbes associated with chronic irreversible pulpitis using metagenomic next-generation sequencing.BMC oral health · 2025Article
- Group-wise normalization in differential abundance analysis of microbiome samples.BMC bioinformatics · 2025Article
- Modifiable early life risk factors for dental calculus in dogs: a retrospective cross-sectional study in Finland.BMC veterinary research · 2025Article
- Endo-Periodontal Lesions in Endodontically Treated Teeth with Periapical Pathology.Diagnostics (Basel, Switzerland) · 2025Article
- Bacterial genera in the fluids from apical periodontitis-related radicular cysts: An observational study.International endodontic journal · 2025Observational
- A polymicrobial perspective into the ecological role of Enterococcus faecalis in dental root canal infections.NPJ biofilms and microbiomes · 2025Review
- Effectiveness of Three Rotary File Systems on Enterococcus Faecalis in Single Rooted Teeth: An In Vitro Study.European endodontic journal · 2025Article
- Microbiological Insights and Diagnostic Approaches in Endo-Perio Lesions.Journal of pharmacy & bioallied sciences · 2025Article
- Association Between Dietary Patterns and Subgingival Microbiota: Results From the Oral Infections, Glucose Intolerance, and Insulin Resistance Study (ORIGINS).Journal of clinical periodontology · 2025Article
- Microbiome differences between trauma- and caries-derived periapical lesions using next-generation sequencing.Journal of oral microbiology · 2025Article
- The potential regulatory role of mannose phosphotransferase system EII in alkaline resistance ofJournal of oral microbiology · 2025Article
- Investigating the Antibacterial Ability of Sodium Hypochlorite Solution Activated with PUI and XPF File AgainstBioengineering (Basel, Switzerland) · 2024Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
introductionThis study was conducted to evaluate the microbiomes of endodontic-periodontal lesions before and after chemomechanical preparation (CMP).
methodsClinical samples were taken from 15 root canals (RCs) with necrotic pulp tissues and from their associated periodontal pockets (PPs) (n = 15) of teeth with endodontic-periodontal lesions before and after CMP. The Human Oral Microbe Identification using Next Generation Sequencing (NGS) protocol and viable culture were used to analyze samples from RCs and PPs. The Mann-Whitney U test and Benjamini-Hochberg corrections were performed to correlate the clinical and radiographic findings with microbial findings (P < .05).
resultsBacteria were detected in 100% of the samples in both sites (15/15) using NGS. Firmicutes was the most predominant phylum in both sites using both methods. The most frequently detected species in the RCs before and after CMP using NGS were Enterococcus faecalis, Parvimonas micra, Mogibacterium timidum, Filifactor alocis, and Fretibacterium fastidiosum. The species most frequently detected in the PPs before and after CMP using NGS were P. micra, E. faecalis, Streptococcus constellatus, Eubacterium brachy, Tannerella forsythia, and F. alocis. Associations were found between periapical lesions ≤ 2 mm and Desulfobulbus sp oral taxon 041 and with periodontal pockets ≥ 6 mm and Dialister invisius and Peptostreptococcus stomatis (all P < .05, found in the RCs before CMP).
conclusionsIt is concluded that the microbial community present in combined endodontic-periodontal lesions is complex and more diverse than previously reported. It is important to note that bacteria do survive in some root canals after CMP. Finally, the similarity between the microbiota of both sites, before and after CMP, suggests there may be a pathway of infection between the pulp and periodontium.
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Registered trials
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