ReviewParticle and fibre toxicology2015
Assessing particle and fiber toxicology in the respiratory system: the stereology toolbox.
Review in Particle and fibre toxicology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Single, double, and triple-hit strategies to establish a long-term premature rabbit model of bronchopulmonary dysplasia.Respiratory research · 2025Article
- Evaluating the role of sex-related structure-function differences on airway aerosol transport and deposition.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Review
- Determination of ragweed allergen Amb a 1 distribution in aerosols using ELISA and immunogold scanning electron microscopy.The journal of allergy and clinical immunology. Global · 2022Article
- A short primer on lung stereology.Respiratory research · 2021Review
- Stereology and three-dimensional reconstructions to analyze the pulmonary vasculature.Histochemistry and cell biology · 2021Review
- Hypoimmune induced pluripotent stem cell-derived cell therapeutics treat cardiovascular and pulmonary diseases in immunocompetent allogeneic mice.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Combination of µCT and light microscopy for generation-specific stereological analysis of pulmonary arterial branches: a proof-of-concept study.Histochemistry and cell biology · 2021Article
- Stereology as the 3D tool to quantitate lung architecture.Histochemistry and cell biology · 2021Review
- Design-Based Stereology of the Lung in the Hyperoxic Preterm Rabbit Model of Bronchopulmonary Dysplasia.Oxidative medicine and cellular longevity · 2021Article
- The association between the diesel exhaust particle exposure from bus emission and the tubular epithelial cell deformation of rats.Environmental science and pollution research international · 2020Article
- miR-21-KO Alleviates Alveolar Structural Remodeling and Inflammatory Signaling in Acute Lung Injury.International journal of molecular sciences · 2020Article
- Acute and chronic changes in the control of breathing in a rat model of bronchopulmonary dysplasia.American journal of physiology. Lung cellular and molecular physiology · 2019Article
- Air-blood barrier thickening and alterations of alveolar epithelial type 2 cells in mouse lungs with disrupted hepcidin/ferroportin regulatory system.Histochemistry and cell biology · 2019Article
- Age-Related Structural and Functional Changes in the Mouse Lung.Frontiers in physiology · 2019Article
- Lipid-body containing interstitial cells (lipofibroblasts) in the lungs of various mouse strains.Journal of anatomy · 2017Article
- Functional vascularized lung grafts for lung bioengineering.Science advances · 2017Article
- Curing the Toxicity of Multi-Walled Carbon Nanotubes through Native Small-molecule Drugs.Scientific reports · 2017Article
- Vagal innervation is required for pulmonary function phenotype inAmerican journal of physiology. Lung cellular and molecular physiology · 2017Article
- Design-Based Stereology for Evaluation of Histological Parameters.Journal of molecular neuroscience : MN · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The inhalation of airborne particles can lead to pathological changes in the respiratory tract. For this reason, toxicology studies on effects of inhalable particles and fibers often include an assessment of histopathological alterations in the upper respiratory tract, the trachea and/or the lungs. Conventional pathological evaluations are usually performed by scoring histological lesions in order to obtain "quantitative" information and an estimation of the severity of the lesion. This approach not only comprises a potential subjective bias, depending on the examiner's judgment, but also conveys the risk that mild alterations escape the investigator's eye. The most accurate way of obtaining unbiased quantitative information about three-dimensional (3D) features of tissues, cells, or organelles from two-dimensional physical or optical sections is by means of stereology, the gold standard of image-based morphometry. Nevertheless, it can be challenging to express histopathological changes by morphometric parameters such as volume, surface, length or number only. In this review we therefore provide an overview on different histopathological lesions in the respiratory tract associated with particle and fiber toxicology and on how to apply stereological methods in order to correctly quantify and interpret histological lesions in the respiratory tract. The article further aims at pointing out common pitfalls in quantitative histopathology and at providing some suggestions on how respiratory toxicology can be improved by stereology. Thus, we hope that this article will stimulate scientists in particle and fiber toxicology research to implement stereological techniques in their studies, thereby promoting an unbiased 3D assessment of pathological lesions associated with particle exposure.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.