ReviewCellular and molecular life sciences : CMLS2016
Brain glucose metabolism during hypoglycemia in type 1 diabetes: insights from functional and metabolic neuroimaging studies.
Review in Cellular and molecular life sciences : CMLS, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02866435 (Identifying the Brain Substrates of Hypoglycemia Unawareness in Type 1 Diabetes), which is not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Identifying the Brain Substrates of Hypoglycemia Unawareness in Type 1 Diabetes
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The historical progression of positron emission tomography research in neuroendocrinology.Frontiers in neuroendocrinology · 2023Pooled it
- Altered Caffeine Metabolism Is Associated With Recurrent Hypoglycemia in Type 2 Diabetes Mellitus: A UPLC-MS-Based Untargeted Metabolomics Study.Frontiers in endocrinology · 2022Trial
- Strategies for optimization of hypoglycemia rat models.Animal models and experimental medicine · 2025Review
- Measurement of brain glucose metabolism in obesity and diabetes.Diabetologia · 2025Review
- A Narrative Review on Cognitive Impairment in Type 2 Diabetes: Global Trends and Diagnostic Approaches.Biomedicines · 2025Review
- Continuous Reduction of Hypoglycemia Incidence Post-Endoscopic Polypectomy Through Quality Control Circle Implementation.Journal of multidisciplinary healthcare · 2025Article
- Effects of a Diabetic Microenvironment on Neurodegeneration: Special Focus on Neurological Cells.Brain sciences · 2024Review
- Metabolomic associations of impaired awareness of hypoglycaemia in type 1 diabetes.Scientific reports · 2024Article
- Effects of Hypoglycemia on Cardiovascular Function in Patients with Diabetes.International journal of molecular sciences · 2023Review
- Alterations in intra- and inter-network connectivity associated with cognition impairment in insulinoma patients.Frontiers in endocrinology · 2023Article
- Remembrance of things past: The consequences of recurrent hypoglycaemia in diabetes.Diabetic medicine : a journal of the British Diabetic Association · 2022Review
- Corresponding risk factors between cognitive impairment and type 1 diabetes mellitus: A narrative review.Heliyon · 2022Review
- The effect of codeine administration on oxidative stress biomarkers and the expression of the neuron-specific enolase in the brain of Wistar rats.Naunyn-Schmiedeberg's archives of pharmacology · 2021Article
- Is Bariatric Surgery Brain Surgery?Diabetes · 2021Article
- Consequences of recurrent hypoglycaemia on brain function in diabetes.Diabetologia · 2021Review
- Article
- Elevated brain glutamate levels in type 1 diabetes: correlations with glycaemic control and age of disease onset but not with hypoglycaemia awareness status.Diabetologia · 2019Article
- The impact of type 1 diabetes on neural activity serving attention.Human brain mapping · 2019Article
- Cost-effectiveness of sensor-augmented insulin pump therapy vs continuous subcutaneous insulin infusion in patients with type 1 diabetes in the Netherlands.ClinicoEconomics and outcomes research : CEOR · 2019Article
- Altered motor dynamics in type 1 diabetes modulate behavioral performance.NeuroImage. Clinical · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypoglycemia is the most frequent complication of insulin therapy in patients with type 1 diabetes. Since the brain is reliant on circulating glucose as its main source of energy, hypoglycemia poses a threat for normal brain function. Paradoxically, although hypoglycemia commonly induces immediate decline in cognitive function, long-lasting changes in brain structure and cognitive function are uncommon in patients with type 1 diabetes. In fact, recurrent hypoglycemia initiates a process of habituation that suppresses hormonal responses to and impairs awareness of subsequent hypoglycemia, which has been attributed to adaptations in the brain. These observations sparked great scientific interest into the brain's handling of glucose during (recurrent) hypoglycemia. Various neuroimaging techniques have been employed to study brain (glucose) metabolism, including PET, fMRI, MRS and ASL. This review discusses what is currently known about cerebral metabolism during hypoglycemia, and how findings obtained by functional and metabolic neuroimaging techniques contributed to this knowledge.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.