Evidence map›Paper›PMID 26520685›Full record

Trial reportPsychoneuroendocrinology2016

Association of HPA axis hormones with copeptin after psychological stress differs by sex.

Elias K Spanakis, Gary S Wand, Nan Ji, Sherita Hill Golden

Open access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psychoneuroendocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Validity of mental and physical stress models.Neuroscience and biobehavioral reviews · 2024
    Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Elias K SpanakisDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Gary S WandDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Nan JiDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Sherita Hill GoldenDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21287, USA. Electronic address: sahill@jhmi.edu.
Johns Hopkins Medicine · USJohns Hopkins University · USUniversity of Maryland, Baltimore · US

Funding

JHU-UMD Diabetes Research CenterP30DK079637 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI BRANCATI, FREDERICK L · 2013 to 2017
$9.7M
Clinical Research&Epidemiology in Diabetes&EndocrinologyT32DK062707 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI TODD T BROWN, Wendy Lynet Bennett · 2002 to 2026
$7.3M
Genes, Stress and PsychopathologyR01MH076953 · NIMH · JOHNS HOPKINS UNIVERSITY · PI WAND, GARY S · 2007 to 2011
$2.4M
Neuroendocrine Investigators and Mentoring in the field of Alcohol ResearchK05AA020342 · NIAAA · JOHNS HOPKINS UNIVERSITY · PI WAND, GARY S · 2011 to 2015
$872k
NIAAA NIH HHS K05 AA020342NIDDK NIH HHS P30 DK079637NIDDK NIH HHS T32 DK062707NIMH NIH HHS BYNIH R01 MH76953NIMH NIH HHS R01 MH076953
6 · The paper itself

Abstract

introductionCopeptin levels are elevated in severe medical conditions, an effect that is attributed to elevated arginine vasopressin (AVP) levels in response to physiological stress, resulting in activation of hypothalamus-pituitary-adrenal (HPA) axis. In the current study, we wanted to determine if copeptin is responsive to psychological stress, correlates with cortisol and adrenocorticotropin hormone (ACTH), and if associations differed by sex. MATERIALS AND

methodsIn a cross-sectional study that included 100 healthy men (41%) and women (59%) (aged 18-30 years; mean 24.6 ± 3 years), who underwent the Trier Social Stress Test (TSST), we examined the association between percent change (peak-baseline/baseline) in copeptin levels and percent change in log ACTH and cortisol. Three baselines samples were drawn followed by blood sampling at 20, 35, 50, 65 and 85 min after TSST.

resultsThere was a significant positive association between the percent change in copeptin and the percent change in log-transformed salivary cortisol (β-coefficient=0.95; p=0.02). The association between percent change in copeptin and log-transformed serum cortisol was not statistically significant in the overall population. There was a trend for a non-significant association between percent change in copeptin and percent change in log-transformed ACTH (β-coefficient=1.14; p=0.06). In males, there was a significant positive association between the percent change in copeptin levels and log-transformed salivary (β-coefficient=1.33, p=0.016) and serum cortisol (β-coefficient=0.69, p=0.01), whereas in women there was no statistically significant association.

conclusionsWe found a significant positive association between percent change in copeptin and percent change in salivary and serum cortisol among males only.

Indexed as

AdolescentAdrenocorticotropic HormoneAdultArginine VasopressinCross-Sectional StudiesFemaleGlycopeptidesHumansHydrocortisoneHypothalamo-Hypophyseal SystemMalePituitary-Adrenal SystemSalivaSex FactorsStress, PsychologicalYoung AdultAdrenocorticotropic HormoneArginine VasopressincopeptinsGlycopeptidesHydrocortisoneCopeptinSex differencesStressTrier Stress Test

Identifiers

PMID26520685
PMCPMC4695232
OpenAlexW2150370302

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.